PDF(Pubmed)
Abstract：
Non-aureus staphylococci and mammaliicocci (NASM) are one of the most common causes of subclinical mastitis in dairy animals and the extent of damage by intramammary infections (IMI) caused by NASM is still under debate. The different effects of NASM on the mammary gland may be associated with differences between bacterial species. NASM are normal and abundant colonizers of humans and animals and become pathogenic only in certain situations. The veterinary interest in NASM has been intense for the last 25 years, due to the strongly increasing rate of opportunistic infections. Therefore, the objective of this review is to provide a general background of the NASM as a cause of mastitis and the most recent advances that exist to prevent and fight the biofilm formation of this group of bacteria, introduce new biomedical applications that could be used in dairy herds to reduce the risk of chronic and recurrent infections, potentially responsible for economic losses due to reduced milk production and quality. Effective treatment of biofilm infection requires a dual approach through a combination of antibiofilm and antimicrobial agents. Even though research on the development of biofilms is mainly focused on human medicine, this technology must be developed at the same time in veterinary medicine, especially in the dairy industry where IMI are extremely common.
摘要：
非金黄色葡萄球菌和哺乳动物球菌（NASM）是奶牛亚临床乳腺炎的最常见原因之一，由NASM引起的乳房内感染（IMI）的损害程度仍在争论中。NASM对乳腺的不同影响可能与细菌种类之间的差异有关。NASM是人类和动物的正常和丰富的定殖者，只有在某些情况下才会致病。在过去的25年里，兽医对NASM的兴趣一直很强烈，由于机会性感染率的急剧增加。因此,这篇综述的目的是提供NASM作为乳腺炎原因的一般背景，以及防止和对抗这组细菌生物膜形成的最新进展，引入新的生物医学应用，可用于奶牛群，以降低慢性和复发性感染的风险，由于牛奶产量和质量下降，可能造成经济损失。生物膜感染的有效治疗需要通过抗生物膜和抗微生物剂的组合的双重方法。尽管对生物膜开发的研究主要集中在人类医学上，这项技术必须在兽医学中同时开发，特别是在乳品行业，IMI是非常普遍的。
