Abstract：
Robust evidence have shown diet or dietary components in playing a direct role on cancer chemoprevention such as breast cancer (BC), and also prevention against cancer therapy side effects. In this context, vitamin E isoforms have been associated with tumor suppression pathways, mainly related to proliferation, invasion, metastasis, tumor metabolism and chemoresistance.
Therefore, we performed a systematic review with meta-analysis to assess the effects of vitamin E consumption and/or supplementation on breast cancer risk, treatment, and outcomes.
The studies were selected in the electronic databases PubMed, Science Direct, Scopus and Web of Science.
A total of 22 articles were selected, which nine manuscripts we perform the meta-analysis. The summary effect estimate did not indicate any significant association between consumption versus non-consumption of total vitamin E and breast cancer risk. After assessing the effects of vitamin E supplementation on breast cancer risk, only two had data for comparison and vitamin E supplementation presented no impact on breast cancer risk. However, the summary effect estimate from the included studies indicated that vitamin E consumption was inversely associated with breast cancer recurrence in the control group. There are no significant results regarding dietary or supplemental vitamin E intake and BC risk reduction.
Finally, regarding recurrence, survival, and mortality, the results indicated that vitamin E consumption was inversely associated with breast cancer recurrence, although no association was found for breast cancer mortality.
Therefore, we performed a systematic review with meta-analysis to assess the effects of vitamin E consumption and/or supplementation on breast cancer risk, treatment, and outcomes.
The studies were selected in the electronic databases PubMed, Science Direct, Scopus and Web of Science.
A total of 22 articles were selected, which nine manuscripts we perform the meta-analysis. The summary effect estimate did not indicate any significant association between consumption versus non-consumption of total vitamin E and breast cancer risk. After assessing the effects of vitamin E supplementation on breast cancer risk, only two had data for comparison and vitamin E supplementation presented no impact on breast cancer risk. However, the summary effect estimate from the included studies indicated that vitamin E consumption was inversely associated with breast cancer recurrence in the control group. There are no significant results regarding dietary or supplemental vitamin E intake and BC risk reduction.
Finally, regarding recurrence, survival, and mortality, the results indicated that vitamin E consumption was inversely associated with breast cancer recurrence, although no association was found for breast cancer mortality.
摘要：
背景：有力的证据表明，饮食或饮食成分在乳腺癌（BC）等癌症化学预防中起直接作用，以及预防癌症治疗副作用。在这种情况下，维生素E亚型与肿瘤抑制途径有关，主要与扩散有关，入侵,转移,肿瘤代谢和化疗耐药。
目标：因此，我们用荟萃分析进行了系统评价，以评估维生素E摄入和/或补充对乳腺癌风险的影响，治疗,和结果。
方法：这些研究是在电子数据库PubMed中选择的，科学直接，Scopus和WebofScience
结果：共入选22篇，其中九份手稿我们进行了荟萃分析。汇总效果估计表明，摄入与不摄入总维生素E和乳腺癌风险之间没有任何显着关联。在评估补充维生素E对乳腺癌风险的影响后，只有两项有比较数据,补充维生素E对乳腺癌风险无影响.然而,纳入研究的汇总效应估计表明,对照组中维生素E摄入与乳腺癌复发呈负相关.关于饮食或补充维生素E摄入和降低BC风险没有显著结果。
结论：最后，关于复发，生存,和死亡率，结果表明，维生素E的消耗与乳腺癌复发呈负相关，尽管没有发现乳腺癌死亡率的相关性。
目标：因此，我们用荟萃分析进行了系统评价，以评估维生素E摄入和/或补充对乳腺癌风险的影响，治疗,和结果。
方法：这些研究是在电子数据库PubMed中选择的，科学直接，Scopus和WebofScience
结果：共入选22篇，其中九份手稿我们进行了荟萃分析。汇总效果估计表明，摄入与不摄入总维生素E和乳腺癌风险之间没有任何显着关联。在评估补充维生素E对乳腺癌风险的影响后，只有两项有比较数据,补充维生素E对乳腺癌风险无影响.然而,纳入研究的汇总效应估计表明,对照组中维生素E摄入与乳腺癌复发呈负相关.关于饮食或补充维生素E摄入和降低BC风险没有显著结果。
结论：最后，关于复发，生存,和死亡率，结果表明，维生素E的消耗与乳腺癌复发呈负相关，尽管没有发现乳腺癌死亡率的相关性。
