{Reference Type}: Meta-Analysis
{Title}: Consumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis.
{Author}: de Oliveira VA;Oliveira IKF;Pereira IC;Mendes LKF;Carneiro da Silva FC;Torres-Leal FL;de Castro E Sousa JM;Paiva AA;
{Journal}: Clin Nutr ESPEN
{Volume}: 54
{Issue}: 0
{Year}: 04 2023
暂无{DOI}: 10.1016/j.clnesp.2023.01.032
{Abstract}: Robust evidence have shown diet or dietary components in playing a direct role on cancer chemoprevention such as breast cancer (BC), and also prevention against cancer therapy side effects. In this context, vitamin E isoforms have been associated with tumor suppression pathways, mainly related to proliferation, invasion, metastasis, tumor metabolism and chemoresistance.<BR>Therefore, we performed a systematic review with meta-analysis to assess the effects of vitamin E consumption and/or supplementation on breast cancer risk, treatment, and outcomes.<BR>The studies were selected in the electronic databases PubMed, Science Direct, Scopus and Web of Science.<BR>A total of 22 articles were selected, which nine manuscripts we perform the meta-analysis. The summary effect estimate did not indicate any significant association between consumption versus non-consumption of total vitamin E and breast cancer risk. After assessing the effects of vitamin E supplementation on breast cancer risk, only two had data for comparison and vitamin E supplementation presented no impact on breast cancer risk. However, the summary effect estimate from the included studies indicated that vitamin E consumption was inversely associated with breast cancer recurrence in the control group. There are no significant results regarding dietary or supplemental vitamin E intake and BC risk reduction.<BR>Finally, regarding recurrence, survival, and mortality, the results indicated that vitamin E consumption was inversely associated with breast cancer recurrence, although no association was found for breast cancer mortality.