Abstract：
This retrospective, observational study evaluated patterns of inpatient versus outpatient tumour lysis syndrome (TLS) monitoring during venetoclax ramp-up in 170 patients with chronic lymphocytic leukaemia. The primary outcome was clinical/biochemical TLS. Two clinical and four biochemical TLS occurred (4.1%). Five of the six events occurred in high-risk patients, four occurred at 20 mg dose and three at the 6-h time-point. Inpatient versus outpatient TLS rates within the high-risk subgroup were 15% and 8%. Risk category was the only predictor of TLS events in multivariate analysis. Outpatient escalation did not associate with clinically meaningful TLS events, suggesting outpatient escalation has manageable associated TLS risks, including in high-risk cohorts. These observations require confirmation in larger studies.
摘要：
这次回顾，观察性研究评估了170例慢性淋巴细胞白血病患者在venetoclax升高期间住院和门诊肿瘤溶解综合征（TLS）监测的模式。主要结果是临床/生化TLS。发生了2例临床和4例生化TLS（4.1％）。六个事件中有五个发生在高危患者中，4例发生在20mg剂量,3例发生在6h时间点.在高风险亚组中，住院病人与门诊TLS的比率分别为15%和8%。在多变量分析中，风险类别是TLS事件的唯一预测因子。门诊升级与有临床意义的TLS事件无关，表明门诊升级具有可管理的相关TLS风险，包括高危人群。这些观察结果需要在更大的研究中得到证实。
