PDF(Pubmed)
Abstract：
UNASSIGNED: Psoas muscle parameters have been proposed as a simple and quick method for sarcopenia assessment. The aim of this study was to assess sarcopenia in cirrhotics by psoas muscle on computed tomography and its impact on mortality.
UNASSIGNED: One hundred and fifty patients (75 cirrhotics, 75 subjects) were assessed for psoas muscle on CT scan. Psoas muscle index (PMI) was calculated as \'total psoas muscle area/(height of subject)2\'. Cut off values for sarcopenia diagnosis were derived from local subjects (n = 75) who did not have cirrhosis/other causes of sarcopenia.
UNASSIGNED: Sarcopenia assessed by PMI was seen in 36% (n = 27) of the cirrhotics. Sarcopenia was significantly higher in patients having Child-Pugh C. Ascites, hepatic encephalopathy (HE) and gastro-intestinal bleed were seen in 48%, 18.7% and 24%, respectively. Sarcopenia was significantly associated with ascites and HE (P < 0.05). Out of the 75 cases, 53 cases completed the follow-up period of 1 year. Among the 20 cases who had sarcopenia, 35% (n = 7) succumbed to liver-related illness during 1 year follow-up, and out of the 33 cases without sarcopenia, only 6% (n = 2) died. The association of sarcopenia and 1 year mortality was statistically significant (P = 0.01).
UNASSIGNED: The PMI, a simple method for sarcopenia assessment detected sarcopenia in 36% of cirrhotics. Patients with sarcopenia had a significantly higher 1 year mortality rate and appropriate prognostication of such patients is needed.
UNASSIGNED: One hundred and fifty patients (75 cirrhotics, 75 subjects) were assessed for psoas muscle on CT scan. Psoas muscle index (PMI) was calculated as \'total psoas muscle area/(height of subject)2\'. Cut off values for sarcopenia diagnosis were derived from local subjects (n = 75) who did not have cirrhosis/other causes of sarcopenia.
UNASSIGNED: Sarcopenia assessed by PMI was seen in 36% (n = 27) of the cirrhotics. Sarcopenia was significantly higher in patients having Child-Pugh C. Ascites, hepatic encephalopathy (HE) and gastro-intestinal bleed were seen in 48%, 18.7% and 24%, respectively. Sarcopenia was significantly associated with ascites and HE (P < 0.05). Out of the 75 cases, 53 cases completed the follow-up period of 1 year. Among the 20 cases who had sarcopenia, 35% (n = 7) succumbed to liver-related illness during 1 year follow-up, and out of the 33 cases without sarcopenia, only 6% (n = 2) died. The association of sarcopenia and 1 year mortality was statistically significant (P = 0.01).
UNASSIGNED: The PMI, a simple method for sarcopenia assessment detected sarcopenia in 36% of cirrhotics. Patients with sarcopenia had a significantly higher 1 year mortality rate and appropriate prognostication of such patients is needed.
摘要：
■腰大肌参数已被提出作为一种简单，快速的肌肉减少症评估方法。这项研究的目的是通过计算机断层扫描评估肝硬化腰大肌减少症及其对死亡率的影响。
■150名患者(75名肝硬化患者，75名受试者）在CT扫描中评估腰大肌。腰大肌指数（PMI）计算为“总腰大肌面积/（受试者身高）2”。肌肉减少症诊断的截止值来自没有肝硬化/其他原因的局部受试者(n=75)。
■通过PMI评估的肌肉减少症在36％（n=27）的肝硬化患者中可见。患有Child-PughC.腹水的患者的肌肉减少症明显更高，肝性脑病（HE）和胃肠道出血见于48%，18.7%和24%，分别。肌肉减少症与腹水和HE显著相关(P<0.05)。在75个案例中，53例完成1年随访。在20例肌少症患者中，35％（n=7）在1年随访期间死于肝脏相关疾病，在没有肌少症的33例中，只有6％（n=2）死亡。肌少症与1年死亡率有统计学意义(P=0.01)。
■PMI，一种简单的评估肌肉减少症的方法在36％的肝硬化患者中检测到肌肉减少症。肌肉减少症患者的1年死亡率明显较高，需要对此类患者进行适当的预后。
■150名患者(75名肝硬化患者，75名受试者）在CT扫描中评估腰大肌。腰大肌指数（PMI）计算为“总腰大肌面积/（受试者身高）2”。肌肉减少症诊断的截止值来自没有肝硬化/其他原因的局部受试者(n=75)。
■通过PMI评估的肌肉减少症在36％（n=27）的肝硬化患者中可见。患有Child-PughC.腹水的患者的肌肉减少症明显更高，肝性脑病（HE）和胃肠道出血见于48%，18.7%和24%，分别。肌肉减少症与腹水和HE显著相关(P<0.05)。在75个案例中，53例完成1年随访。在20例肌少症患者中，35％（n=7）在1年随访期间死于肝脏相关疾病，在没有肌少症的33例中，只有6％（n=2）死亡。肌少症与1年死亡率有统计学意义(P=0.01)。
■PMI，一种简单的评估肌肉减少症的方法在36％的肝硬化患者中检测到肌肉减少症。肌肉减少症患者的1年死亡率明显较高，需要对此类患者进行适当的预后。
