PDF(Pubmed)
Abstract：
Here we report on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging. The intervention consisted of an 8-week program that included diet, sleep, exercise and relaxation guidance, supplemental probiotics and phytonutrients and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline [a]) was conducted on blood samples at baseline and at the end of the 8-week period. Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants\' mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.
摘要：
在这里，我们报告了一个由六名女性组成的案例系列，这些女性完成了旨在影响DNA甲基化和生物衰老措施的甲基化支持饮食和生活方式计划。干预包括一个为期8周的计划，包括饮食，睡眠,锻炼和放松指导，补充益生菌和植物营养素和营养指导。DNA甲基化和生物学年龄分析(HorvathDNAmAge时钟(2013)，使用SeSAMe管道[a]）在基线和8周周期结束时对血液样本进行标准化。六名参与者中的五名表现出生物学年龄从基线生物学年龄减少1.22至11.01岁。在8周饮食和生活方式干预之前（55.83岁）和之后（51.23岁），参与者的平均生物学年龄差异有统计学意义（p=0.039）。平均减少4.60年。该计划开始时的平均实际年龄为57.9岁，除一名参与者外，所有参与者的生物学年龄都比计划开始时的实际年龄小，这表明生物学年龄变化与疾病改善无关,而可能归因于潜在的衰老机制.
