Abstract：
OBJECTIVE: Previous studies have suggested that patients with aspirin-exacerbated respiratory disease (AERD) have a high likelihood of alcohol intolerance. The purpose of this systematic review is to identify if there is sufficient evidence to confirm this correlation and the impact of medical therapy on subsequent alcohol tolerance.
METHODS: PubMed, EMBASE, SCOPUS, EBSCO, Google Scholar, Cochrane Library, and Grey literature. We also performed snowballing on the identified observational studies (OS) for additional data.
METHODS: A systematic review was conducted from 1968 to 2022 to identify those studies describing AERD symptomatology triggered by alcohol intake. The primary outcome was to analyze the current literature for the association between alcohol intolerance and AERD symptoms. The secondary outcome looked for improvement in alcohol tolerance after aspirin desensitization or biological therapy.
RESULTS: A total of 775 studies were identified and 40 abstracts were evaluated. From these, 5 studies met the inclusion criteria. Of the 5 manuscripts, there was 1 case-control, 2 cohort, and 2 cross-sectional studies. A total of 522 participants with AERD and a history of alcohol consumption were included, with 52.8% reporting at least 1 sinopulmonary exacerbation after alcohol intake. One of 3 studies noted improvement in alcohol tolerance after medical therapy with aspirin desensitization.
CONCLUSIONS: The current literature suggests that patients with AERD have a high risk of alcohol intolerance. Additionally, aspirin desensitization may improve alcohol tolerance in this patient population.
METHODS: PubMed, EMBASE, SCOPUS, EBSCO, Google Scholar, Cochrane Library, and Grey literature. We also performed snowballing on the identified observational studies (OS) for additional data.
METHODS: A systematic review was conducted from 1968 to 2022 to identify those studies describing AERD symptomatology triggered by alcohol intake. The primary outcome was to analyze the current literature for the association between alcohol intolerance and AERD symptoms. The secondary outcome looked for improvement in alcohol tolerance after aspirin desensitization or biological therapy.
RESULTS: A total of 775 studies were identified and 40 abstracts were evaluated. From these, 5 studies met the inclusion criteria. Of the 5 manuscripts, there was 1 case-control, 2 cohort, and 2 cross-sectional studies. A total of 522 participants with AERD and a history of alcohol consumption were included, with 52.8% reporting at least 1 sinopulmonary exacerbation after alcohol intake. One of 3 studies noted improvement in alcohol tolerance after medical therapy with aspirin desensitization.
CONCLUSIONS: The current literature suggests that patients with AERD have a high risk of alcohol intolerance. Additionally, aspirin desensitization may improve alcohol tolerance in this patient population.
摘要：
目的：先前的研究表明，阿司匹林加重的呼吸系统疾病（AERD）患者酒精不耐受的可能性很高。本系统评价的目的是确定是否有足够的证据证实这种相关性以及药物治疗对随后的酒精耐受性的影响。
方法：PubMed，EMBASE,Scopus,EBSCO,谷歌学者，科克伦图书馆,灰色文学我们还对确定的观察性研究（OS）进行了滚雪球运动，以获取其他数据。
方法：从1968年至2022年进行了系统评价，以确定那些描述酒精摄入引发的AERD症状学的研究。主要结果是分析当前文献中酒精不耐受和AERD症状之间的关联。次要结果是阿司匹林脱敏或生物治疗后酒精耐受性的改善。
结果：共确定了775项研究，评估了40篇摘要。从这些,5项研究符合纳入标准。在5份手稿中，有一个病例控制，2个队列，和2个横断面研究。共有522名患有AERD和饮酒史的参与者被包括在内。52.8％的人报告酒精摄入后至少1次窦肺加重。3项研究中的一项注意到阿司匹林脱敏药物治疗后酒精耐受性的改善。
结论：目前的文献表明，AERD患者存在酒精不耐受的高风险。此外,阿司匹林脱敏可能会改善该患者人群的酒精耐受性。
方法：PubMed，EMBASE,Scopus,EBSCO,谷歌学者，科克伦图书馆,灰色文学我们还对确定的观察性研究（OS）进行了滚雪球运动，以获取其他数据。
方法：从1968年至2022年进行了系统评价，以确定那些描述酒精摄入引发的AERD症状学的研究。主要结果是分析当前文献中酒精不耐受和AERD症状之间的关联。次要结果是阿司匹林脱敏或生物治疗后酒精耐受性的改善。
结果：共确定了775项研究，评估了40篇摘要。从这些,5项研究符合纳入标准。在5份手稿中，有一个病例控制，2个队列，和2个横断面研究。共有522名患有AERD和饮酒史的参与者被包括在内。52.8％的人报告酒精摄入后至少1次窦肺加重。3项研究中的一项注意到阿司匹林脱敏药物治疗后酒精耐受性的改善。
结论：目前的文献表明，AERD患者存在酒精不耐受的高风险。此外,阿司匹林脱敏可能会改善该患者人群的酒精耐受性。
