PDF(Pubmed)
Abstract：
Long-increasing dementia incidence and prevalence trends may be shifting. Whether such shifts have reached the very old is unknown.
To investigate temporal trends in the incidence of dementia and cognitive impairment and prevalence of dementia, cognitive impairment, Alzheimer\'s disease, vascular dementia, and unclassified dementia among 85-, 90-, and ≥ 95-year-olds in Sweden during 2000-2017.
This study was conducted with Umeå 85 + /Gerontological Regional Database data from 2182 85-, 90-, and ≥ 95-year-olds in Sweden collected in 2000-2017. Using logistic regression, trends in the cumulative 5-year incidences of dementia and cognitive impairment; prevalences of dementia, cognitive impairment, Alzheimer\'s disease, and vascular dementia; and Mini-Mental State Examination thresholds for dementia diagnosis were estimated.
Dementia and cognitive impairment incidences decreased in younger groups, which generally showed more-positive temporal trends. The prevalences of overall dementia, cognitive impairment, and Alzheimer\'s disease were stable or increasing; longer disease durations and increasing dementia subtype classification success may mask positive changes in incidences. Vascular dementia increased while unclassified dementia generally decreased.
The cognitive health of the very old may be changing in the 21st century, possibly indicating a trend break.
To investigate temporal trends in the incidence of dementia and cognitive impairment and prevalence of dementia, cognitive impairment, Alzheimer\'s disease, vascular dementia, and unclassified dementia among 85-, 90-, and ≥ 95-year-olds in Sweden during 2000-2017.
This study was conducted with Umeå 85 + /Gerontological Regional Database data from 2182 85-, 90-, and ≥ 95-year-olds in Sweden collected in 2000-2017. Using logistic regression, trends in the cumulative 5-year incidences of dementia and cognitive impairment; prevalences of dementia, cognitive impairment, Alzheimer\'s disease, and vascular dementia; and Mini-Mental State Examination thresholds for dementia diagnosis were estimated.
Dementia and cognitive impairment incidences decreased in younger groups, which generally showed more-positive temporal trends. The prevalences of overall dementia, cognitive impairment, and Alzheimer\'s disease were stable or increasing; longer disease durations and increasing dementia subtype classification success may mask positive changes in incidences. Vascular dementia increased while unclassified dementia generally decreased.
The cognitive health of the very old may be changing in the 21st century, possibly indicating a trend break.
摘要：
背景：长期增加的痴呆发病率和患病率趋势可能正在转变。这种转变是否已经到了非常古老的阶段还不得而知。
目的：研究痴呆和认知障碍的发病率和痴呆患病率的时间趋势，认知障碍，老年痴呆症,血管性痴呆,85-未分类的痴呆症，90-,2000-2017年瑞典≥95岁。
方法：本研究是使用来自218285-的Ume奥85/老年学区域数据库数据进行的。90-,瑞典≥95岁的老年人在2000-2017年收集。使用逻辑回归，痴呆和认知障碍的累积5年发病率的趋势；痴呆的患病率，认知障碍，老年痴呆症,和血管性痴呆；并估计了痴呆诊断的简易精神状态检查阈值。
结果：年轻群体的痴呆和认知障碍发病率下降，通常表现出更积极的时间趋势。整体痴呆症的患病率，认知障碍，和阿尔茨海默病稳定或增加;更长的疾病持续时间和增加的痴呆亚型分类成功可能掩盖发病率的积极变化。血管性痴呆增加，而未分类痴呆通常减少。
结论：在21世纪，老年人的认知健康可能正在发生变化，可能表明趋势突破。
目的：研究痴呆和认知障碍的发病率和痴呆患病率的时间趋势，认知障碍，老年痴呆症,血管性痴呆,85-未分类的痴呆症，90-,2000-2017年瑞典≥95岁。
方法：本研究是使用来自218285-的Ume奥85/老年学区域数据库数据进行的。90-,瑞典≥95岁的老年人在2000-2017年收集。使用逻辑回归，痴呆和认知障碍的累积5年发病率的趋势；痴呆的患病率，认知障碍，老年痴呆症,和血管性痴呆；并估计了痴呆诊断的简易精神状态检查阈值。
结果：年轻群体的痴呆和认知障碍发病率下降，通常表现出更积极的时间趋势。整体痴呆症的患病率，认知障碍，和阿尔茨海默病稳定或增加;更长的疾病持续时间和增加的痴呆亚型分类成功可能掩盖发病率的积极变化。血管性痴呆增加，而未分类痴呆通常减少。
结论：在21世纪，老年人的认知健康可能正在发生变化，可能表明趋势突破。
