PDF(Pubmed)
Abstract：
Post-stroke cognitive impairment, is a major complication of stroke, characterized by cognitive dysfunction, which directly affects the quality of life. Post-stroke cognitive impairment highlights the causal relationship between stroke and cognitive impairment. The pathological damage of stroke, including the increased release of excitatory amino acids, oxidative stress, inflammatory responses, apoptosis, changed neurotrophic factor levels and gene expression, influence synaptic plasticity. Synaptic plasticity refers to the activity-dependent changes in the strength of synaptic connections and efficiency of synaptic transmission at pre-existing synapses and can be divided into structural synaptic plasticity and functional synaptic plasticity. Changes in synaptic plasticity have been proven to play important roles in the occurrence and treatment of post-stroke cognitive impairment. Evidence has indicated that Chinese herbal drugs have effect of treating post-stroke cognitive impairment. In this review, we overview the influence of pathological damage of stroke on synaptic plasticity, analyze the changes of synaptic plasticity in post-stroke cognitive impairment, and summarize the commonly used Chinese herbal drugs whose active ingredient or extracts can regulate synaptic plasticity. This review will summarize the relationship between post-stroke cognitive impairment and synaptic plasticity, provide new ideas for future exploration of the mechanism of post-stroke cognitive impairment, compile evidence of applying Chinese herbal drugs to treat post-stroke cognitive impairment and lay a foundation for the development of novel formulas for treating post-stroke cognitive impairment.
摘要：
卒中后认知障碍,是中风的主要并发症，以认知功能障碍为特征，直接影响生活质量。卒中后认知障碍突出了卒中与认知障碍之间的因果关系。中风的病理损害，包括增加兴奋性氨基酸的释放，氧化应激，炎症反应，凋亡，改变神经营养因子水平和基因表达，影响突触可塑性。突触可塑性是指突触连接强度和突触传递效率在预先存在的突触上的活动依赖性变化，可分为结构突触可塑性和功能突触可塑性。突触可塑性的变化已被证明在卒中后认知障碍的发生和治疗中起重要作用。有证据表明中药有治疗脑卒中后认知功能障碍的作用。在这次审查中,我们概述了中风的病理损伤对突触可塑性的影响，分析卒中后认知障碍患者突触可塑性的变化,并总结了常用的中草药，其活性成分或提取物可以调节突触可塑性。本文就卒中后认知障碍与突触可塑性的关系作一综述,为今后探索卒中后认知障碍的机制提供新的思路,收集应用中药治疗卒中后认知障碍的证据，为开发治疗卒中后认知障碍的新配方奠定基础。
