Abstract：
OBJECTIVE: Dental caries is the most common chronic disease in humans, caused by the acid produced by the microflora in the mouth that dissolves the enamel minerals. Bioactive glass (BAG) has been used in various clinical applications due to its unique bioactive properties, such as bone graft substitutes and dental restorative composites. In this study, we introduce a novel bioactive glass-ceramic (NBGC) prepared through a sol-gel process under a water-free condition.
METHODS: The anti-demineralization and remineralization effects of NBGC were evaluated by comparing the measurements of bovine enamel surface morphology, surface roughness, surface micro-hardness, enamel elements, and mineral content before and after related treatments with a commercial BAG. The antibacterial effect was characterized by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).
RESULTS: Results showed that NBGC had greater acid resistance and remineralization potential compared to commercial BAG. The fast formation of a hydroxy carbonate apatite (HCA) layer suggests efficient bioactivity.
CONCLUSIONS: In addition to its antibacterial properties, NBGC shows promise as an ingredient in oral care products that can prevent demineralization and restore enamel.
METHODS: The anti-demineralization and remineralization effects of NBGC were evaluated by comparing the measurements of bovine enamel surface morphology, surface roughness, surface micro-hardness, enamel elements, and mineral content before and after related treatments with a commercial BAG. The antibacterial effect was characterized by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).
RESULTS: Results showed that NBGC had greater acid resistance and remineralization potential compared to commercial BAG. The fast formation of a hydroxy carbonate apatite (HCA) layer suggests efficient bioactivity.
CONCLUSIONS: In addition to its antibacterial properties, NBGC shows promise as an ingredient in oral care products that can prevent demineralization and restore enamel.
摘要：
目的：龋齿是人类最常见的慢性疾病，由口腔中溶解牙釉质矿物质的微生物产生的酸引起的。生物活性玻璃（BAG）由于其独特的生物活性特性，已用于各种临床应用，如骨移植替代品和牙科修复复合材料。在这项研究中,我们介绍了在无水条件下通过溶胶-凝胶工艺制备的新型生物活性玻璃陶瓷（NBGC）。
方法：通过比较牛牙釉质表面形态的测量来评估NBGC的抗脱矿质和再矿化作用，表面粗糙度,表面显微硬度，搪瓷元素,以及用商业BAG进行相关处理之前和之后的矿物质含量。抗菌作用的特征在于最小抑制浓度(MIC)和最小杀菌浓度(MBC)。
结果：结果表明，与商业BAG相比，NBGC具有更大的耐酸性和再矿化潜力。羟基碳酸盐磷灰石(HCA)层的快速形成表明有效的生物活性。
结论：除了其抗菌性能外，NBGC作为口腔护理产品中的成分显示出希望，可以防止脱矿质并恢复牙釉质。
方法：通过比较牛牙釉质表面形态的测量来评估NBGC的抗脱矿质和再矿化作用，表面粗糙度,表面显微硬度，搪瓷元素,以及用商业BAG进行相关处理之前和之后的矿物质含量。抗菌作用的特征在于最小抑制浓度(MIC)和最小杀菌浓度(MBC)。
结果：结果表明，与商业BAG相比，NBGC具有更大的耐酸性和再矿化潜力。羟基碳酸盐磷灰石(HCA)层的快速形成表明有效的生物活性。
结论：除了其抗菌性能外，NBGC作为口腔护理产品中的成分显示出希望，可以防止脱矿质并恢复牙釉质。
