PDF(Pubmed)
Abstract：
Smoking increases lipid levels, including triglycerides, leading to increased cardiovascular disease risk. We performed a meta-analysis to quantify the effects of smoking and smoking cessation on triglyceride levels. The PubMed and Scopus databases were searched to identify studies reporting either triglyceride levels in smokers and non-smokers or the effects of smoking cessation on triglyceride levels. Fixed- and random-effects models were used to perform the analyses when three or more studies/comparisons were available. We identified 169 and 21 studies evaluating the effects of smoking and smoking cessation, respectively, on triglyceride levels. Triglyceride levels were 0.50 mmol/L (95% confidence interval: 0.49-0.50 mmol/L) higher in smokers than non-smokers, but the effect differed widely across studies. No statistically significant effect was observed on triglyceride levels between baseline and 6 weeks (mean difference [MD] = 0.02 [-0.09, 0.12] mmol/L), 2 months (MD = 0.03 [-0.21, 0.27] mmol/L), 3 months (MD = 0.08 [-0.03, 0.21] mmol/L), or 1 year (MD = 0.04 [-0.06, 0.14] mmol/L) after quitting. However, a slightly significant decrease in triglyceride levels was observed at 1 month after cessation (MD = -0.15 [-0.15, -0.01] mmol/L). The results of this meta-analysis provide a basis for understanding the effects of smoking and smoking cessation on triglyceride levels, which could have important implications for public health.
摘要：
吸烟会增加血脂水平，包括甘油三酯,导致心血管疾病风险增加。我们进行了荟萃分析，以量化吸烟和戒烟对甘油三酸酯水平的影响。搜索PubMed和Scopus数据库以确定报告吸烟者和非吸烟者的甘油三酯水平或戒烟对甘油三酯水平的影响的研究。当三个或更多的研究/比较可用时,使用固定和随机效应模型进行分析。我们确定了169和21项评估吸烟和戒烟效果的研究，分别,甘油三酯水平。吸烟者的甘油三酯水平比不吸烟者高0.50mmol/L（95％置信区间：0.49-0.50mmol/L），但不同研究的效果差异很大。在基线和6周之间，对甘油三酯水平没有观察到统计学上显著的影响（平均差[MD]=0.02[-0.09,0.12]mmol/L），2个月（MD=0.03[-0.21,0.27]mmol/L），3个月（MD=0.08[-0.03,0.21]mmol/L），或戒烟后1年(MD=0.04[-0.06,0.14]mmol/L)。然而,停药后1个月观察到甘油三酯水平略有显著下降(MD=-0.15[-0.15,-0.01]mmol/L).这项荟萃分析的结果为了解吸烟和戒烟对甘油三酯水平的影响提供了基础。这可能对公共卫生产生重要影响。
