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Abstract：
BACKGROUND: Primary malignant melanoma of the esophagus (PMME) is a rare malignant disease whose clinical and molecular pathological features, origin and pathogenesis, diagnosis and treatment have not been elucidated.
METHODS: In this paper, we report a case of a 73-year-old male with PMME. The patient complained of progressive dysphagia accompanied by substantial weight loss. Gastroscopy revealed a purple black bulging-type mass in the lower esophagus with easy bleeding on contact and scattered satellite lesions in the stomach. Histopathological biopsy revealed melanocytes in the esophageal mucosa. Physical examination and multidisciplinary consultation led to diagnostic exclusion of melanoma originating in other organs, such as the skin. Through this case report and literature review, we aimed to describe the clinical and molecular pathological features of PMME and summarize possible pathways of pathogenesis as well as cutting-edge therapeutic advances.
CONCLUSIONS: PMME is a rare malignancy of the esophagus with a poor prognosis. Clinicians should raise their awareness and be able to identify early lesions.
METHODS: In this paper, we report a case of a 73-year-old male with PMME. The patient complained of progressive dysphagia accompanied by substantial weight loss. Gastroscopy revealed a purple black bulging-type mass in the lower esophagus with easy bleeding on contact and scattered satellite lesions in the stomach. Histopathological biopsy revealed melanocytes in the esophageal mucosa. Physical examination and multidisciplinary consultation led to diagnostic exclusion of melanoma originating in other organs, such as the skin. Through this case report and literature review, we aimed to describe the clinical and molecular pathological features of PMME and summarize possible pathways of pathogenesis as well as cutting-edge therapeutic advances.
CONCLUSIONS: PMME is a rare malignancy of the esophagus with a poor prognosis. Clinicians should raise their awareness and be able to identify early lesions.
摘要：
背景：原发性食管恶性黑色素瘤（PMME）是一种罕见的恶性疾病，其临床和分子病理学特征，起源和发病机制，诊断和治疗尚未阐明。
方法：在本文中，我们报告一例73岁男性患有PMME.患者主诉进行性吞咽困难并伴有大量体重减轻。胃镜检查发现食管下段紫色黑色膨出型肿块，接触时容易出血，胃内有散在的卫星病变。组织病理学活检显示食管粘膜中的黑素细胞。体格检查和多学科咨询导致诊断排除起源于其他器官的黑色素瘤，比如皮肤。通过本病例报告和文献综述,我们旨在描述PMME的临床和分子病理学特征，总结可能的发病机制以及前沿治疗进展。
结论：PMME是一种罕见的食管恶性肿瘤，预后不良。临床医生应提高认识，并能够识别早期病变。
方法：在本文中，我们报告一例73岁男性患有PMME.患者主诉进行性吞咽困难并伴有大量体重减轻。胃镜检查发现食管下段紫色黑色膨出型肿块，接触时容易出血，胃内有散在的卫星病变。组织病理学活检显示食管粘膜中的黑素细胞。体格检查和多学科咨询导致诊断排除起源于其他器官的黑色素瘤，比如皮肤。通过本病例报告和文献综述,我们旨在描述PMME的临床和分子病理学特征，总结可能的发病机制以及前沿治疗进展。
结论：PMME是一种罕见的食管恶性肿瘤，预后不良。临床医生应提高认识，并能够识别早期病变。
