%0 Case Reports
%T Primary malignant melanoma of the esophagus: A case report.
%A Wang QQ
%A Li YM
%A Qin G
%A Liu F
%A Xu YY
%J World J Clin Cases
%V 11
%N 6
%D Feb 2023 26
%M 36926119
%F 1.534
%R 10.12998/wjcc.v11.i6.1426
%X <B>BACKGROUND: </B>Primary malignant melanoma of the esophagus (PMME) is a rare malignant disease whose clinical and molecular pathological features, origin and pathogenesis, diagnosis and treatment have not been elucidated.<BR><B>METHODS: </B>In this paper, we report a case of a 73-year-old male with PMME. The patient complained of progressive dysphagia accompanied by substantial weight loss. Gastroscopy revealed a purple black bulging-type mass in the lower esophagus with easy bleeding on contact and scattered satellite lesions in the stomach. Histopathological biopsy revealed melanocytes in the esophageal mucosa. Physical examination and multidisciplinary consultation led to diagnostic exclusion of melanoma originating in other organs, such as the skin. Through this case report and literature review, we aimed to describe the clinical and molecular pathological features of PMME and summarize possible pathways of pathogenesis as well as cutting-edge therapeutic advances.<BR><B>CONCLUSIONS: </B>PMME is a rare malignancy of the esophagus with a poor prognosis. Clinicians should raise their awareness and be able to identify early lesions.