Abstract：
Alzheimer\'s disease (AD) is a chronic and irreversible neurodegenerative disorder with progressive dementia and cognitive impairment. AD poses severe health challenge in elderly people and become one of the leading causes of death worldwide. It possesses complex pathophysiology with several hypotheses (cholinergic hypothesis, amyloid hypothesis, tau hypothesis, oxidative stress, mitochondrial dysfunction etc.). Several attempts have been made for the management of multifactorial AD. Acetylcholinesterase is the only target has been widely explored in the management of AD to the date. The current review set forth the chalcone based natural, semi-synthetic and synthetic compounds in the search of potential anti-Alzheimer\'s agents. The main highlights of current review emphasizes on chalcone target different enzymes and pathways like Acetylcholinesterase, β-secretase (BACE1), tau proteins, MAO, free radicals, Advanced glycation end Products (AGEs) etc. and their structure activity relationships contributing in the inhibition of above mentioned various targets of AD.
摘要：
阿尔茨海默病(Alzheimer\'sdisease,AD)是一种慢性且不可逆的神经退行性疾病,伴有进行性痴呆和认知障碍。AD对老年人构成了严峻的健康挑战，并成为全球主要的死亡原因之一。它具有复杂的病理生理学，有几个假设(胆碱能假说，淀粉样蛋白假说，tau假说,氧化应激，线粒体功能障碍等.).已经对多因素AD的管理进行了一些尝试。乙酰胆碱酯酶是迄今为止在AD管理中被广泛探索的唯一靶点。当前的审查提出了基于查尔酮的自然，半合成和合成化合物在潜在的抗阿尔茨海默病药物的搜索。当前综述的主要亮点强调查尔酮靶向不同的酶和途径，如乙酰胆碱酯酶，β-分泌酶(BACE1),tau蛋白,MAO,自由基,晚期糖基化终产物(AGEs)等.以及它们的结构活性关系有助于抑制上述各种AD靶标。
