Abstract：
Elaborative affective processing is observed in depression, and pupillary reactivity, a continuous, sensitive, and reliable indicator of physiological arousal and neurocognitive processing, is increasingly utilized in studies of depression-related characteristics. As a first attempt to quantitively summarize existing evidence on depression-related pupillary reactivity alterations, this review and meta-analysis evaluated the direction, magnitude, and specificity of pupillary indices of affective processing towards positively, negatively, and neutrally-valenced stimuli among individuals diagnosed with depression or with elevated risk of depression. Studies on pupillary responses to affective stimuli in the target groups were identified in PsycINFO and PubMed databases. Twenty-two articles met inclusion criteria for the qualitative review and 16 for the quantitative review. Three-level frequentist and Bayesian models were applied to summarize pooled effects from baseline-controlled stimuli-induced average changes in pupillary responses. In general, compared to non-depressed individuals, individuals with depression or elevated risk of depression exhibited higher pupillary reactivity (d =0.15) towards negatively-valenced stimuli during affective processing. Pupillary motility towards negatively-valenced stimuli may be a promising trait-like marker for depression vulnerability.
摘要：
在抑郁症中观察到精心设计的情感加工，和瞳孔反应性,一个连续的，敏感,生理唤醒和神经认知过程的可靠指标，越来越多地用于抑郁症相关特征的研究。作为首次尝试定量总结抑郁症相关瞳孔反应性改变的现有证据，这篇综述和荟萃分析评估了方向，量级,和情感加工的瞳孔指数对积极的特异性，消极的,在被诊断患有抑郁症或抑郁症风险升高的个体中，刺激是中性的。在PsycINFO和PubMed数据库中确定了目标人群对情感刺激的瞳孔反应研究。22篇文章符合定性审查的纳入标准，16篇符合定量审查的纳入标准。应用三级频率和贝叶斯模型来总结基线控制刺激引起的瞳孔反应平均变化的综合影响。总的来说,与非抑郁个体相比，抑郁或抑郁风险升高的个体在情感加工过程中对负价刺激表现出更高的瞳孔反应性(d=0.15).对负价刺激的瞳孔运动可能是抑郁症脆弱性的有希望的性状样标记。
