染色体 2p14 上调节 SPRED2 和 ACTR2 的增强子变体充当信号放大器以防止类风湿性关节炎。
关键词: ACTR2 SNP SPRED2 enhancer rheumatoid arthritis signal amplifier synovial fibroblasts variant
Mesh : Humans Arthritis, Rheumatoid / genetics metabolism Cell Proliferation / genetics Cells, Cultured Chromosomes Fibroblasts / metabolism Gene Expression Regulation Genome-Wide Association Study Repressor Proteins / genetics Synoviocytes / metabolism pathology Actin-Related Protein 2 / metabolism
来 源:
DOI:10.1016/j.ajhg.2023.02.012
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