PDF(Pubmed)
Abstract：
Autoimmune enteropathy is a rare cause of malabsorption usually associated with circulating autoantibodies and predisposition to autoimmune disorders. The diagnosis is based on the following criteria: chronic diarrhea (>6 months), malabsorption, specific histological findings, anti-enterocyte and anti-goblet cell antibodies, and exclusion of similar disorders. We report a case of a 73-year-old woman presenting with severe chronic diarrhea, weight loss, and electrolyte abnormalities. Endoscopy revealed duodenal villous atrophy extending to proximal jejunum, and duodenal biopsies revealed villous blunting, cryptitis with apoptosis, and scattered intraepithelial lymphocytes. Therapeutic management included immunosuppressive treatment with corticosteroids, achieving clinical remission.
摘要：
自身免疫性肠病是吸收不良的罕见原因，通常与循环自身抗体和自身免疫性疾病的易感性有关。诊断基于以下标准：慢性腹泻（>6个月），吸收不良,特定的组织学发现，抗肠细胞和抗杯状细胞抗体，并排除类似的疾病。我们报告了一例73岁的女性，表现为严重的慢性腹泻，减肥,和电解质异常。内镜检查显示十二指肠绒毛萎缩延伸至近端空肠，十二指肠活检显示绒毛钝化，隐膜炎伴细胞凋亡，和分散的上皮内淋巴细胞。治疗包括皮质类固醇的免疫抑制治疗，实现临床缓解。
