Abstract：
Chronic hepatitis B (HBV) infection is a disease that imposes a considerable financial burden on patients and can lead to sleep disorders (SDs), resulting in a serious deterioration to patient quality of life. This study aimed to determine the prevalence of SDs in patients with HBV and the correlated sociodemographic and clinical characteristics. A total of 747 patients with chronic HBV infection were recruited. All patients completed the Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 scale, Social Support Rating Scale, Short Form 36 Health Survey (SF-36), and Visual Analogue Scale (VAS). The total PSQI score of patients with each type of chronic HBV infection was significantly higher compared to healthy Chinese adults (p < .05). The incidence of SDs in HBV carriers and patients with mild HBV, moderate HBV, severe HBV, liver failure, compensated cirrhosis, and decompensated liver cirrhosis was 25%, 26%, 32%, 47%, 56%, 31%, and 49%, respectively. The incidence of SDs in all patients with chronic HBV infection was 30%. Binary logistic regression analysis revealed that the course of disease, aspartate aminotransferase levels, PHQ-9 scores, and VAS scores were independent risk factors for SDs, while the total SF-36 score was a protective factor for SDs (all p < .05). In conclusion, the prevalence of SDs was significantly higher in patients with chronic hepatitis B compared to healthy subjects. The independent risk factors for SDs included disease duration, aspartate aminotransferase levels, depression, and fatigue. Clinicians should pay more attention to SDs in patients with chronic HBV infection.
摘要：
慢性乙型肝炎（HBV）感染是一种对患者施加相当大的经济负担的疾病，并可能导致睡眠障碍（SDs），导致患者生活质量严重恶化。本研究旨在确定HBV患者中SDs的患病率以及相关的社会人口统计学和临床特征。共招募747例慢性HBV感染患者。所有患者均完成匹兹堡睡眠质量指数（PSQI），患者健康问卷-9（PHQ-9），广义焦虑症-7量表，社会支持评定量表,简短表格36健康调查(SF-36)，和视觉模拟量表(VAS)。各型慢性HBV感染者的PSQI总分明显高于健康中国成年人(P<0.05)。HBV携带者和轻度HBV患者中SDs的发生率，中度HBV，严重的HBV，肝功能衰竭,代偿性肝硬化,失代偿期肝硬化占25%，26%,32%,47%,56%,31%,49%,分别。所有慢性HBV感染患者的SDs发生率为30％。二元logistic回归分析显示，病程，天冬氨酸转氨酶水平，PHQ-9得分,和VAS评分是SDs的独立危险因素，SF-36总分是SD的保护因素(均P<0.05)。总之,与健康受试者相比，慢性乙型肝炎患者的SDs患病率明显更高。SDs的独立危险因素包括疾病持续时间，天冬氨酸转氨酶水平，抑郁症,和疲劳。临床医生应重视慢性HBV感染患者的SDs。
