Abstract：
BACKGROUND: The study aims to investigate the relationship between the volume-accumulated reflectivity (termed \"integral\") on spectral domain optical coherence tomography (SD-OCT) and cone density on adaptive optics (AO) imaging.
METHODS: In this cross-sectional study, both eyes of 32 healthy subjects and 5 patients with inherited retinal diseases (IRD) were studied. The parameter, integral, was defined as the volume-accumulated reflectivity values in a selected region on OCT images; integrals of the ellipsoid zone (EZ) and interdigitation zone (IZ) were measured at 2°, 3°, 4°, 5°and 6° eccentricity along the four meridians on fovea-centered OCT B-scans. Cone density in the same region was measured using a flood illumination adaptive optics camera RTX1.
RESULTS: Integrals of EZ, IZ and cone density shared similar distribution patterns. Integral of the IZ was better correlated with cone density in both healthy people (r = 0.968, p < 0.001) and those with IRD (r = 0.823, p < 0.001) than direct measurements of reflectivity on OCT images. A strong correlation was found between best corrected visual acuity (BCVA) and cone density at 2° eccentricity (r = -0.857, p = 0.002). BCVA was also correlated with the integral of the IZ at the foveola (r = -0.746, p = 0.013) and fovea (r = -0.822, p = 0.004).
CONCLUSIONS: The new parameter \"integral\" of the photoreceptor outer segment measured from SD-OCT was noted to correlate with cone density and visual function in this pilot study.
METHODS: In this cross-sectional study, both eyes of 32 healthy subjects and 5 patients with inherited retinal diseases (IRD) were studied. The parameter, integral, was defined as the volume-accumulated reflectivity values in a selected region on OCT images; integrals of the ellipsoid zone (EZ) and interdigitation zone (IZ) were measured at 2°, 3°, 4°, 5°and 6° eccentricity along the four meridians on fovea-centered OCT B-scans. Cone density in the same region was measured using a flood illumination adaptive optics camera RTX1.
RESULTS: Integrals of EZ, IZ and cone density shared similar distribution patterns. Integral of the IZ was better correlated with cone density in both healthy people (r = 0.968, p < 0.001) and those with IRD (r = 0.823, p < 0.001) than direct measurements of reflectivity on OCT images. A strong correlation was found between best corrected visual acuity (BCVA) and cone density at 2° eccentricity (r = -0.857, p = 0.002). BCVA was also correlated with the integral of the IZ at the foveola (r = -0.746, p = 0.013) and fovea (r = -0.822, p = 0.004).
CONCLUSIONS: The new parameter \"integral\" of the photoreceptor outer segment measured from SD-OCT was noted to correlate with cone density and visual function in this pilot study.
摘要：
背景：本研究旨在研究频域光学相干断层扫描（SD-OCT）上的体积累积反射率（称为“积分”）与自适应光学（AO）成像上的视锥密度之间的关系。
方法：在这项横断面研究中，研究了32例健康受试者和5例遗传性视网膜疾病（IRD）患者的双眼。参数,积分,定义为OCT图像上选定区域的体积累积反射率值；在2°处测量椭球区(EZ)和交叉区(IZ)的积分，3°,4°,在中心凹的OCTB扫描上，沿四个子午线的5°和6°偏心率。使用泛光照明自适应光学相机RTX1测量同一区域中的锥体密度。
结果：EZ的积分，IZ和锥体密度具有相似的分布模式。与直接测量OCT图像的反射率相比，在健康人（r=0.968，p<0.001）和IRD患者（r=0.823，p<0.001）中，IZ积分与视锥密度的相关性更好。最佳矫正视力（BCVA）与2°偏心率下的视锥密度之间存在很强的相关性（r=-0.857，p=0.002）。BCVA还与中央凹（r=-0.746，p=0.013）和中央凹（r=-0.822，p=0.004）处的IZ积分相关。
结论：在这项初步研究中，根据SD-OCT测量的感光体外段的新参数“积分”与视锥密度和视觉功能相关。
方法：在这项横断面研究中，研究了32例健康受试者和5例遗传性视网膜疾病（IRD）患者的双眼。参数,积分,定义为OCT图像上选定区域的体积累积反射率值；在2°处测量椭球区(EZ)和交叉区(IZ)的积分，3°,4°,在中心凹的OCTB扫描上，沿四个子午线的5°和6°偏心率。使用泛光照明自适应光学相机RTX1测量同一区域中的锥体密度。
结果：EZ的积分，IZ和锥体密度具有相似的分布模式。与直接测量OCT图像的反射率相比，在健康人（r=0.968，p<0.001）和IRD患者（r=0.823，p<0.001）中，IZ积分与视锥密度的相关性更好。最佳矫正视力（BCVA）与2°偏心率下的视锥密度之间存在很强的相关性（r=-0.857，p=0.002）。BCVA还与中央凹（r=-0.746，p=0.013）和中央凹（r=-0.822，p=0.004）处的IZ积分相关。
结论：在这项初步研究中，根据SD-OCT测量的感光体外段的新参数“积分”与视锥密度和视觉功能相关。
