METHODS: In this cross-sectional study, both eyes of 32 healthy subjects and 5 patients with inherited retinal diseases (IRD) were studied. The parameter, integral, was defined as the volume-accumulated reflectivity values in a selected region on OCT images; integrals of the ellipsoid zone (EZ) and interdigitation zone (IZ) were measured at 2°, 3°, 4°, 5°and 6° eccentricity along the four meridians on fovea-centered OCT B-scans. Cone density in the same region was measured using a flood illumination adaptive optics camera RTX1.
RESULTS: Integrals of EZ, IZ and cone density shared similar distribution patterns. Integral of the IZ was better correlated with cone density in both healthy people (r = 0.968, p < 0.001) and those with IRD (r = 0.823, p < 0.001) than direct measurements of reflectivity on OCT images. A strong correlation was found between best corrected visual acuity (BCVA) and cone density at 2° eccentricity (r = -0.857, p = 0.002). BCVA was also correlated with the integral of the IZ at the foveola (r = -0.746, p = 0.013) and fovea (r = -0.822, p = 0.004).
CONCLUSIONS: The new parameter \"integral\" of the photoreceptor outer segment measured from SD-OCT was noted to correlate with cone density and visual function in this pilot study.
方法:在这项横断面研究中,研究了32例健康受试者和5例遗传性视网膜疾病(IRD)患者的双眼。参数,积分,定义为OCT图像上选定区域的体积累积反射率值;在2°处测量椭球区(EZ)和交叉区(IZ)的积分,3°,4°,在中心凹的OCTB扫描上,沿四个子午线的5°和6°偏心率。使用泛光照明自适应光学相机RTX1测量同一区域中的锥体密度。
结果:EZ的积分,IZ和锥体密度具有相似的分布模式。与直接测量OCT图像的反射率相比,在健康人(r=0.968,p<0.001)和IRD患者(r=0.823,p<0.001)中,IZ积分与视锥密度的相关性更好。最佳矫正视力(BCVA)与2°偏心率下的视锥密度之间存在很强的相关性(r=-0.857,p=0.002)。BCVA还与中央凹(r=-0.746,p=0.013)和中央凹(r=-0.822,p=0.004)处的IZ积分相关。
结论:在这项初步研究中,根据SD-OCT测量的感光体外段的新参数“积分”与视锥密度和视觉功能相关。