在有效的 COVID - 19 药物再利用中快速鉴定潜在候选者的应用。
关键词: 2DG, 2-Deoxy-Glucose ACE2, Angiotensin-converting enzyme 2 COVID-19 COVID-19, Coronavirus disease 2019 Caco-2, Human colon epithelial carcinoma cell line Calu-3, Epithelial cell line Cellular SARS-CoV-2 signatures Cellular host-immune response Cellular simulation models DEGs, Differentially Expressed Genes DEPs, Differentially expressed proteins Drug repurposing HCQ-CQ, (Hydroxy)chloroquine IFN, Interferon ISGs, IFN-stimulated genes MITHrIL, Mirna enrIched paTHway Impact anaLysis MOI, Multiplicity of infection MP, Methylprednisolone NHBE, Normal human bronchial epithelial cells PHENSIM, PHENotype SIMulator SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Systems biology TLR, Toll-like Receptor
来 源:
DOI:10.1016/j.heliyon.2023.e14115
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