PDF(Pubmed)
Abstract：
Interferons (IFNs) are important in controlling the innate immune response to viral infections. Besides that, studies have found that IFNs also have antimicrobial, antiproliferative/antitumor and immunomodulatory effects. IFNs are divided into Type I, II and III. Type I IFNs, in particular IFN-α, is an approved treatment for hepatitis C. However, patients developed neuropsychological disorders during treatment. IFN-α induces proinflammatory cytokines, indoleamine 2,3-dioxygenase (IDO), oxidative and nitrative stress that intensifies the body\'s inflammatory response in the treatment of chronic inflammatory disease. The severity of the immune response is related to behavioral changes in both animal models and humans. Reactive oxygen species (ROS) is important for synaptic plasticity and long-term potentiation (LTP) in the hippocampus. However, excess ROS will generate highly reactive free radicals which may lead to neuronal damage and neurodegeneration. The limbic system regulates memory and emotional response, damage of neurons in this region is correlated with mood disorders. Due to the drawbacks of the treatment, often patients will not complete the treatment sessions, and this affects their recovery process. However, with proper management, this could be avoided. This review briefly describes the different types of IFNs and its pharmacological and clinical usages and a focus on IFN-α and its implications on depression.
摘要：
干扰素(IFN)在控制对病毒感染的先天免疫应答中是重要的。除此之外,研究发现IFNs也有抗菌作用，抗增殖/抗肿瘤和免疫调节作用。IFN分为I型，II和III。I型IFNs,特别是IFN-α，是一种经批准的丙型肝炎治疗方法，患者在治疗期间出现神经心理障碍.IFN-α诱导促炎细胞因子，吲哚胺2,3-双加氧酶（IDO），氧化和硝化应激，在慢性炎性疾病的治疗中加剧身体的炎症反应。免疫反应的严重程度与动物模型和人类的行为变化有关。活性氧（ROS）对海马的突触可塑性和长时程增强（LTP）很重要。然而,过量的ROS会产生高度反应性的自由基，这可能导致神经元损伤和神经变性。边缘系统调节记忆和情绪反应，该区域神经元的损伤与情绪障碍有关。由于治疗的弊端，患者通常不会完成治疗，这会影响他们的康复过程。然而,通过适当的管理，这是可以避免的。这篇综述简要介绍了不同类型的IFN及其药理和临床用途，并重点介绍了IFN-α及其对抑郁症的影响。
