We included 653 patients who underwent both oral cytological and histological examinations. Data on sex, specimen collection region, cytological and histological diagnoses, and histological images were reviewed.
The overall male-to-female ratio was 1:1.18. The tongue was the most common specimen collection region, followed by the gingiva and buccal mucosa. The most common cytological examination result was negative (66.8%), followed by doubtful (22.7%) and positive (10.3%). The sensitivity, specificity, positive predictive value, and negative predictive value of cytological diagnosis were 69%, 75%, 38%, and 92%, respectively. Approximately 8.3% of patients with a negative cytological diagnosis had a histological diagnosis of oral squamous cell carcinoma. Furthermore, 86.1% of histopathologic images of cytology-negative squamous cell carcinomas exhibited well-differentiated keratinocytes lacking atypia on the surface. The remaining patients developed recurrence, or they had low cell counts.
Liquid-based cytology is useful in screening oral cancer. However, a cytological diagnosis of superficial-differentiated oral squamous cell carcinoma is occasionally inconsistent with the histological diagnosis. Therefore, histological and cytological examinations should be performed if tumor-like lesions are suspected clinically.
方法:我们纳入了653例接受口腔细胞学和组织学检查的患者。性别数据,标本采集区,细胞学和组织学诊断,和组织学图像进行了审查。
结果:总体男女比例为1:1.18。舌头是最常见的标本采集区域,其次是牙龈和颊粘膜。最常见的细胞学检查结果为阴性(66.8%),其次是可疑(22.7%)和阳性(10.3%)。敏感性,特异性,正预测值,细胞学诊断的阴性预测值为69%,75%,38%,92%,分别。细胞学诊断阴性的患者中约有8.3%的组织学诊断为口腔鳞状细胞癌。此外,86.1%的细胞学阴性鳞状细胞癌的组织病理学图像显示出分化良好的角质形成细胞,表面缺乏异型性。其余患者出现复发,或者细胞计数低.
结论:液基细胞学检查可用于筛查口腔癌。然而,浅表分化口腔鳞状细胞癌的细胞学诊断有时与组织学诊断不一致.因此,如果临床怀疑肿瘤样病变,应进行组织学和细胞学检查。