We used short-form Problem Behaviors Assessment mental health symptom data from the international Enroll-HD data set to characterize mental health symptoms across eight HD groups: Stages 1-5, premanifest and genotype-negative individuals, and family controls (n = 8567) using chi-square analysis with post hoc comparisons.
We identified that people with later-stage HD (Stages 2-5) had significantly higher apathy, obsessive-compulsiveness, and (from Stage 3) disorientation than the remaining groups at a medium effect size, and that these findings largely held across three measure administrations over time.
These findings highlight the critical symptoms in manifest HD from Stage 2 onward, but also demonstrate that crucial symptoms such as depression, anxiety, and irritability are present across HD-affected groups (including noncarriers of the gene expansion). The outcomes highlight a need for specific clinical management of later-stage HD psychological symptoms, and for systemic support across affected families.
方法:我们使用了来自国际注册HD数据集的简短形式的问题行为评估心理健康症状数据来表征八个HD组的心理健康症状:1-5阶段,入列前和基因型阴性个体,和家庭对照(n=8567)使用卡方分析和事后比较。
结果:我们发现晚期HD(2-5期)患者的冷漠程度明显更高,强迫症,并且(从第3阶段开始)比其余组具有中等效果大小的迷失方向,随着时间的推移,这些发现在三个措施管理部门中基本保持不变。
结论:这些发现强调了从第2阶段开始,表现为HD的危重症状,但也证明了抑郁症等关键症状,焦虑,和烦躁不安存在于受HD影响的人群中(包括基因扩增的非携带者)。结果强调需要对晚期HD心理症状进行特定的临床管理,以及受影响家庭的系统性支持。