关键词： A-H, Alpers-Huttenlocher syndrome AD, Alzheimer’s disease ALS, Amyotrophic lateral sclerosis BBB, blood-brain barrier C. elegans,, Caenorhabditis elegans CJD, Creutzfeldt-Jakob disease CMT, Charcot–Marie–Tooth disease CS, Cockayne syndrome Ech A, Echinochrome A FDA, Food and Drug Administration FRDA, Friedreich’s ataxia FTD, Frontotemporal dementia HD, Huntington’s disease Hsp, Heat shock protein LSD, Lysosomal storage diseases MS, Multiple sclerosis MSA, Multiple system atrophy MSP, Multisystem proteinopathy Medicinal plant ND, neurodegenerative disease NPC, Neimann-Pick disease type C NSC, neural stem cells Neuro-inflammation Neurodegeneration Neurogenesis PC, pharmacological chaperone PD, Parkinson’s disease Protein misfolding SMA, Spinal muscular atrophy VD, Vascular dementia prion dis, prion diseases α-syn, alpha-synuclein

来  源：   DOI：10.1016/j.ibneur.2023.01.006   PDF(Pubmed)

Abstract：
Some of the greatest challenges in medicine are the neurodegenerative diseases (NDs), which remain without a cure and mostly progress to death. A companion study employed a toolkit methodology to document 2001 plant species with ethnomedicinal uses for alleviating pathologies relevant to NDs, focusing on its relevance to Alzheimer\'s disease (AD). This study aimed to find plants with therapeutic bioactivities for a range of NDs. 1339 of the 2001 plant species were found to have a bioactivity from the literature of therapeutic relevance to NDs such as Parkinson\'s disease, Huntington\'s disease, AD, motor neurone diseases, multiple sclerosis, prion diseases, Neimann-Pick disease, glaucoma, Friedreich\'s ataxia and Batten disease. 43 types of bioactivities were found, such as reducing protein misfolding, neuroinflammation, oxidative stress and cell death, and promoting neurogenesis, mitochondrial biogenesis, autophagy, longevity, and anti-microbial activity. Ethno-led plant selection was more effective than random selection of plant species. Our findings indicate that ethnomedicinal plants provide a large resource of ND therapeutic potential. The extensive range of bioactivities validate the usefulness of the toolkit methodology in the mining of this data. We found that a number of the documented plants are able to modulate molecular mechanisms underlying various key ND pathologies, revealing a promising and even profound capacity to halt and reverse the processes of neurodegeneration.
摘要：
医学中一些最大的挑战是神经退行性疾病（ND），仍然没有治愈，大部分进展到死亡。一项伴随研究采用了一种工具包方法来记录2001年具有种族医学用途的植物物种，以减轻与ND相关的病理，重点关注其与阿尔茨海默病(AD)的相关性。这项研究旨在寻找对一系列ND具有治疗性生物活性的植物。2001年植物物种中的1339种被发现具有治疗相关的生物活性，如帕金森病，亨廷顿病,AD,运动神经元疾病,多发性硬化症,朊病毒病,Neimann-Pick病,青光眼,弗里德赖希的共济失调和巴滕病。发现了43种生物活性，比如减少蛋白质的错误折叠，神经炎症，氧化应激和细胞死亡，促进神经发生，线粒体生物发生，自噬,长寿，和抗微生物活性。Ethno主导的植物选择比植物物种的随机选择更有效。我们的发现表明，食草植物提供了大量ND治疗潜力的资源。广泛的生物活性验证了工具包方法在挖掘此数据中的有用性。我们发现，许多有文献记载的植物能够调节各种关键ND病理的分子机制，揭示了一种有希望甚至深刻的能力来阻止和逆转神经变性的过程。
公众号