PDF(Pubmed)
Abstract：
Metastatic spinal melanoma is a rare and aggressive disease process with poor prognosis. We review the literature on metastatic spinal melanoma, focusing on its epidemiology, management, and treatment outcomes. Demographics of metastatic spinal melanoma are similar to those for cutaneous melanoma, and cutaneous primary tumors tend to be most common. Decompressive surgical intervention and radiotherapy have traditionally been considered mainstays of treatment, and stereotactic radiosurgery has emerged as a promising approach in the operative management of metastatic spinal melanoma. While survival outcomes for metastatic spinal melanoma remain poor, they have improved in recent years with the advent of immune checkpoint inhibition, used in conjunction with surgery and radiotherapy. New treatment options remain under investigation, especially for patients with disease refractory to immunotherapy. We additionally explore several of these promising future directions. Nevertheless, further investigation of treatment outcomes, ideally incorporating high-quality prospective data from randomized controlled trials, is needed to identify optimal management of metastatic spinal melanoma.
摘要：
转移性脊柱黑色素瘤是一种罕见的侵袭性疾病，预后不良。我们回顾了转移性脊柱黑色素瘤的文献，专注于其流行病学，管理,和治疗结果。转移性脊柱黑色素瘤的人口统计学特征与皮肤黑色素瘤相似，皮肤原发性肿瘤往往是最常见的。传统上，减压手术干预和放疗被认为是治疗的支柱。立体定向放射外科已成为转移性脊柱黑色素瘤手术治疗的一种有前途的方法。虽然转移性脊柱黑色素瘤的生存结果仍然很差，近年来随着免疫检查点抑制的出现，它们有所改善，与手术和放疗结合使用。新的治疗方案仍在调查中，特别是对于免疫疗法难以治疗的患者。我们还探索了其中几个有希望的未来方向。然而，进一步调查治疗结果，理想情况下，结合来自随机对照试验的高质量前瞻性数据，需要确定转移性脊柱黑色素瘤的最佳管理。
