PDF(Pubmed)
Abstract：
Tumor necrosis factor-alpha (TNF-alpha) antagonist use is prevalent for the treatment of autoimmune diseases, including psoriasis, ankylosing spondylitis, and rheumatoid arthritis. Since the onset of its use over the last couple of decades, there have been increasing reports of drug-induced antibodies and antitumor necrosis factor-alpha-induced lupus (ATIL). Herein, we present a case of pericarditis induced by tumor necrosis factor-alpha antagonist, adalimumab. A 61-year-old male with psoriatic arthritis treated with adalimumab injections for five years presented with dyspnea, chest tightness, and three-pillow orthopnea. Echocardiogram showed moderate pericardial effusion with early signs of tamponade. Adalimumab was discontinued. He was started on colchicine and steroids for a high suspicion of drug-induced serositis. With the increased use of tumor necrosis factor-alpha antagonists, adverse reactions such as ATIL will become more common. Such cases need to be reported to spread awareness of this possible complication and avoid any delay in treatment and care.
摘要：
肿瘤坏死因子-α（TNF-α）拮抗剂的使用普遍用于治疗自身免疫性疾病，包括牛皮癣,强直性脊柱炎,和类风湿性关节炎。自从它在过去的几十年中开始使用以来，关于药物诱导的抗体和抗肿瘤坏死因子-α诱导的狼疮(ATIL)的报道越来越多.在这里，我们介绍一例由肿瘤坏死因子-α拮抗剂引起的心包炎，阿达木单抗。一名61岁的男性患有银屑病关节炎，接受阿达木单抗注射治疗五年，表现为呼吸困难，胸闷,和三枕正位呼吸。超声心动图显示中度心包积液，早期有填塞征象。阿达木单抗停药。他开始服用秋水仙碱和类固醇，因为高度怀疑药物引起的浆膜炎。随着肿瘤坏死因子-α拮抗剂使用的增加,ATIL等不良反应将变得更加常见。需要报告此类病例，以传播对这种可能的并发症的认识，并避免治疗和护理的任何延误。
