PDF(Pubmed)
Abstract：
Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.
摘要：
成人T细胞急性淋巴细胞白血病（T-ALL）的维持治疗是最长的阶段，但选择有限。在维持阶段使用的经典药物，如6-巯基嘌呤，甲氨蝶呤,皮质类固醇和长春新碱具有潜在的严重毒性。在现代优化治疗，T-ALL患者的无化疗维持治疗方案可显著改善维持治疗前景.我们在此报告抗程序性细胞死亡蛋白1抗体和组蛋白去乙酰化酶抑制剂的组合作为T-ALL患者的无化疗维持治疗，并进行文献综述。因此，除了有价值的信息之外，还提供了一个独特的视角，这些信息可能会为新的治疗方法提供信息。
