{Reference Type}: Case Reports
{Title}: Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review.
{Author}: Song Y;Chen S;Liu C;Chen L;Wang W;Wu B;Liang Y;
{Journal}: Front Pharmacol
{Volume}: 14
{Issue}: 0
{Year}: 2023
{Factor}: 5.988
{DOI}: 10.3389/fphar.2023.1051305
{Abstract}: Maintenance therapy in adult T-cell acute lymphoblastic leukemia (T-ALL) is the longest phase but with limited option. The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. Optimizing therapy in the modern age, chemo-free maintenance therapy regimens for patients with T-ALL may dramatically improve the maintenance therapeutic landscape. We report here the combination of Anti-programmed cell death protein 1 antibody and histone deacetylase inhibitor as chemo-free maintenance treatment in a T-ALL patient with literature review, thus providing a unique perspective in addition to valuable information which may inform novel therapeutic approaches.