PDF(Pubmed)
Abstract：
UNASSIGNED: Whether complete revascularization (CR) or incomplete revascularization (IR) may affect long-term outcomes after PCI) and coronary artery bypass grafting (CABG) for left main coronary artery (LMCA) disease is unclear.
UNASSIGNED: The authors sought to assess the impact of CR or IR on 10-year outcomes after PCI or CABG for LMCA disease.
UNASSIGNED: In the PRECOMBAT (Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease) 10-year extended study, the authors evaluated the effect of PCI and CABG on long-term outcomes according to completeness of revascularization. The primary outcome was the incidence of major adverse cardiac or cerebrovascular events (MACCE) (composite of mortality from any cause, myocardial infarction, stroke, or ischemia-driven target vessel revascularization).
UNASSIGNED: Among 600 randomized patients (PCI, n = 300 and CABG, n = 300), 416 patients (69.3%) had CR and 184 (30.7%) had IR; 68.3% of PCI patients and 70.3% of CABG patients underwent CR, respectively. The 10-year MACCE rates were not significantly different between PCI and CABG among patients with CR (27.8% vs 25.1%, respectively; adjusted HR: 1.19; 95% CI: 0.81-1.73) and among those with IR (31.6% vs 21.3%, respectively; adjusted HR: 1.64; 95% CI: 0.92-2.92) (P for interaction = 0.35). There was also no significant interaction between the status of CR and the relative effect of PCI and CABG on all-cause mortality, serious composite of death, myocardial infarction, or stroke, and repeat revascularization.
UNASSIGNED: In this 10-year follow-up of PRECOMBAT, the authors found no significant difference between PCI and CABG in the rates of MACCE and all-cause mortality according to CR or IR status. (Ten-Year Outcomes of PRE-COMBAT Trial [PRECOMBAT], NCT03871127; PREmier of Randomized COMparison of Bypass Surgery Versus AngioplasTy Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease [PRECOMBAT], NCT00422968).
UNASSIGNED: The authors sought to assess the impact of CR or IR on 10-year outcomes after PCI or CABG for LMCA disease.
UNASSIGNED: In the PRECOMBAT (Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease) 10-year extended study, the authors evaluated the effect of PCI and CABG on long-term outcomes according to completeness of revascularization. The primary outcome was the incidence of major adverse cardiac or cerebrovascular events (MACCE) (composite of mortality from any cause, myocardial infarction, stroke, or ischemia-driven target vessel revascularization).
UNASSIGNED: Among 600 randomized patients (PCI, n = 300 and CABG, n = 300), 416 patients (69.3%) had CR and 184 (30.7%) had IR; 68.3% of PCI patients and 70.3% of CABG patients underwent CR, respectively. The 10-year MACCE rates were not significantly different between PCI and CABG among patients with CR (27.8% vs 25.1%, respectively; adjusted HR: 1.19; 95% CI: 0.81-1.73) and among those with IR (31.6% vs 21.3%, respectively; adjusted HR: 1.64; 95% CI: 0.92-2.92) (P for interaction = 0.35). There was also no significant interaction between the status of CR and the relative effect of PCI and CABG on all-cause mortality, serious composite of death, myocardial infarction, or stroke, and repeat revascularization.
UNASSIGNED: In this 10-year follow-up of PRECOMBAT, the authors found no significant difference between PCI and CABG in the rates of MACCE and all-cause mortality according to CR or IR status. (Ten-Year Outcomes of PRE-COMBAT Trial [PRECOMBAT], NCT03871127; PREmier of Randomized COMparison of Bypass Surgery Versus AngioplasTy Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease [PRECOMBAT], NCT00422968).
摘要：
UNASSIGNED：完全血运重建（CR）或不完全血运重建（IR）是否会影响PCI后的长期结局）和冠状动脉旁路移植术（CABG）治疗左主干冠状动脉（LMCA）疾病尚不清楚。
UNASSIGNED：作者试图评估CR或IR对LMCA疾病PCI或CABG术后10年结局的影响。
UNASSIGNED：在PRECOMBAT（左主干冠状动脉疾病患者使用西罗莫司洗脱支架进行旁路手术与血管成形术的随机比较）中，为期10年的扩展研究，作者根据血运重建的完整性评估了PCI和CABG对长期结局的影响.主要结局是主要不良心脑血管事件（MACCE）的发生率（任何原因的复合死亡率，心肌梗塞,中风,或缺血驱动的靶血管血运重建)。
未经证实：在600名随机患者中（PCI，n=300和CABG，n=300),416例(69.3%)患者有CR,184例(30.7%)患者有IR;68.3%的PCI患者和70.3%的CABG患者有CR,分别。在CR患者中，PCI和CABG之间的10年MACCE率没有显着差异（27.8％vs25.1％，分别；调整后的HR：1.19；95%CI：0.81-1.73)和有IR的人群(31.6%vs21.3%，分别；调整后的HR：1.64；95%CI：0.92-2.92）（交互作用的P=0.35）。CR状态与PCI和CABG对全因死亡率的相对影响之间也没有显着交互作用。严重的复合死亡，心肌梗塞,或中风，并重复血运重建。
未经评估：在这10年的后续行动中，作者发现,根据CR或IR状态,PCI和CABG在MACCE和全因死亡率方面没有显著差异.(预打击试验[预打击]十年成果，NCT03871127;左主干冠状动脉疾病患者使用西罗莫司洗脱支架进行旁路手术与血管成形术的随机组合比较[PRECOMBAT]，NCT00422968)。
UNASSIGNED：作者试图评估CR或IR对LMCA疾病PCI或CABG术后10年结局的影响。
UNASSIGNED：在PRECOMBAT（左主干冠状动脉疾病患者使用西罗莫司洗脱支架进行旁路手术与血管成形术的随机比较）中，为期10年的扩展研究，作者根据血运重建的完整性评估了PCI和CABG对长期结局的影响.主要结局是主要不良心脑血管事件（MACCE）的发生率（任何原因的复合死亡率，心肌梗塞,中风,或缺血驱动的靶血管血运重建)。
未经证实：在600名随机患者中（PCI，n=300和CABG，n=300),416例(69.3%)患者有CR,184例(30.7%)患者有IR;68.3%的PCI患者和70.3%的CABG患者有CR,分别。在CR患者中，PCI和CABG之间的10年MACCE率没有显着差异（27.8％vs25.1％，分别；调整后的HR：1.19；95%CI：0.81-1.73)和有IR的人群(31.6%vs21.3%，分别；调整后的HR：1.64；95%CI：0.92-2.92）（交互作用的P=0.35）。CR状态与PCI和CABG对全因死亡率的相对影响之间也没有显着交互作用。严重的复合死亡，心肌梗塞,或中风，并重复血运重建。
未经评估：在这10年的后续行动中，作者发现,根据CR或IR状态,PCI和CABG在MACCE和全因死亡率方面没有显著差异.(预打击试验[预打击]十年成果，NCT03871127;左主干冠状动脉疾病患者使用西罗莫司洗脱支架进行旁路手术与血管成形术的随机组合比较[PRECOMBAT]，NCT00422968)。
