在基于 LC - MS 的临床研究中 , 用于可靠测量代谢物和脂质的分析前样品处理标准化。
关键词: 1-AG, 1-arachidonoyl glycerol 1-LG, 1-linoleoyl glycerol 2-AG, 2-arachidonoyl glycerol 2-LG, 2- linoleoyl glycerol ACN, acetonitrile AEA, arachidonoyl ethanolamide BHT, 2,6-di-tert-butyl-4-methylphenol CAR, carnitine EC, endocannabinoid FC, fold change FT, freezing temperature/storage in ice water HETE, hydroxyeicosatetraenoate HRMS, high-resolution mass spectrometry IRB, Institutional Review Board IS, internal standard K3EDTA plasma sampling K3EDTA, tripotassium ethylenediaminetetraacetic acid LC, liquid chromatography LEA, linoleoyl ethanolamide LLE, liquid–liquid extraction LLOQ, lowest limit of quantification LPA, lysophosphatidic acid LPC O, lysophosphatidylcholine-ether LPC, lysophosphatidylcholine LPE, lysophosphatidylethanolamine LPG, lysophosphatidylglycerol LPI, lysophosphatic inositol Lipidomics MS/MS, tandem mass spectrometry MTBE, methyl tertiary-butyl ether MeOH, methanol Metabolomics OEA, oleoyl ethanolamide PBS, phosphate-buffered saline PC, phohsphatidylcholine PE, phosphotidylethanolamine PEA, palmitoyl ethanolamide PI, phosphatidylinositol Pre-analytics QC, quality control REC, Research Ethics Committee RT, room temperature Ref, reference sample SEA, stearoyl ethanolamide SPE, solid-phase extraction STD, calibration standard Sampling protocol VEA, vaccenic acid ethanolamid WB, whole blood
来 源:
DOI:10.1016/j.jmsacl.2023.02.002
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