Abstract：
This review systematically examined the associations between chronic stress and hair cortisol concentration (HCC) in children, and the potential modification effects of type, measurement period and scales of chronic stress, child age and sex, hair length and HCC measurement method, characteristics of study site, and congruence between time periods measured for chronic stress and HCC.
Pubmed, Wed of Science, and APA PsycINFO were systematically searched for articles examining the association between chronic stress and HCC.
Thirteen studies from five countries with 1,455 participants were included in the systematic review and nine studies were included in the meta-analysis. Meta-analysis revealed that chronic stress was associated with HCC (pooled-r = 0.09, 95 % CI: 0.03, 0.16). Stratified analyses revealed that type, measurement time and scales of chronic stress, hair length and measurement method of HCC, and the congruence between time periods measured for chronic stress and HCC modified such correlations. The positive correlations between chronic stress and HCC were significant for studies measuring chronic stress as stressful life events, assessing chronic stress within the past six months, extracting HCC from 1 cm, 3 cm, or 6 cm of hair, measuring HCC by LC-MS/MS, or having congruence between time periods measured for chronic stress and HCC. The potential modifying effects of sex and country developmental status could not be concluded due to the limited number of studies included.
Chronic stress was positively correlated with HCC, varying by characteristics and measurements of chronic stress and HCC. HCC could be a biomarker for chronic stress among children.
Pubmed, Wed of Science, and APA PsycINFO were systematically searched for articles examining the association between chronic stress and HCC.
Thirteen studies from five countries with 1,455 participants were included in the systematic review and nine studies were included in the meta-analysis. Meta-analysis revealed that chronic stress was associated with HCC (pooled-r = 0.09, 95 % CI: 0.03, 0.16). Stratified analyses revealed that type, measurement time and scales of chronic stress, hair length and measurement method of HCC, and the congruence between time periods measured for chronic stress and HCC modified such correlations. The positive correlations between chronic stress and HCC were significant for studies measuring chronic stress as stressful life events, assessing chronic stress within the past six months, extracting HCC from 1 cm, 3 cm, or 6 cm of hair, measuring HCC by LC-MS/MS, or having congruence between time periods measured for chronic stress and HCC. The potential modifying effects of sex and country developmental status could not be concluded due to the limited number of studies included.
Chronic stress was positively correlated with HCC, varying by characteristics and measurements of chronic stress and HCC. HCC could be a biomarker for chronic stress among children.
摘要：
目的：这篇综述系统地研究了儿童慢性应激与毛发皮质醇浓度（HCC）之间的关系，以及类型的潜在修饰效果，慢性压力的测量周期和尺度，儿童年龄和性别，头发长度和HCC测量方法，研究地点的特点，以及慢性应激和HCC测量的时间段之间的一致性。
方法：发布，科学大会,和APAPsycINFO进行了系统搜索，以检查慢性应激与HCC之间的关联。
结果：系统评价纳入了来自5个国家的13项研究，1455名参与者，其中9项研究纳入了荟萃分析。Meta分析显示，慢性应激与HCC相关（合并r=0.09，95%CI：0.03，0.16）。分层分析揭示了这种类型，慢性压力的测量时间和尺度，原发性肝癌的头发长度和测量方法，慢性应激和HCC测量的时间段之间的一致性改变了这种相关性。慢性应激与HCC之间的正相关对于将慢性应激作为应激性生活事件进行测量的研究具有重要意义。评估过去六个月内的慢性压力，从1厘米处提取肝癌，3厘米,或6厘米的头发，通过LC-MS/MS测量HCC，或在慢性应激和HCC测量的时间段之间具有一致性。由于所包括的研究数量有限，无法得出性别和国家发展状况的潜在改变作用。
结论：慢性应激与HCC呈正相关，因慢性应激和肝癌的特点和测量而异。HCC可能是儿童慢性应激的生物标志物。
方法：发布，科学大会,和APAPsycINFO进行了系统搜索，以检查慢性应激与HCC之间的关联。
结果：系统评价纳入了来自5个国家的13项研究，1455名参与者，其中9项研究纳入了荟萃分析。Meta分析显示，慢性应激与HCC相关（合并r=0.09，95%CI：0.03，0.16）。分层分析揭示了这种类型，慢性压力的测量时间和尺度，原发性肝癌的头发长度和测量方法，慢性应激和HCC测量的时间段之间的一致性改变了这种相关性。慢性应激与HCC之间的正相关对于将慢性应激作为应激性生活事件进行测量的研究具有重要意义。评估过去六个月内的慢性压力，从1厘米处提取肝癌，3厘米,或6厘米的头发，通过LC-MS/MS测量HCC，或在慢性应激和HCC测量的时间段之间具有一致性。由于所包括的研究数量有限，无法得出性别和国家发展状况的潜在改变作用。
结论：慢性应激与HCC呈正相关，因慢性应激和肝癌的特点和测量而异。HCC可能是儿童慢性应激的生物标志物。
