This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA®) guidelines and was registered at the International Prospective Register of Systematic Reviews (PROSPERO). The search for articles was performed in PubMed, Lilacs, Embase and SciELO databases. From the 2,485 articles identified, 25 were selected according to the inclusion and exclusion criteria.
The analysis of these articles indicated that potential vaccine designs in development are available, although there is still a paucity of studies in the human clinical trial phase.
Although HTLV-1 was discovered almost 40 years ago, it remains a great challenge and a worldwide neglected threat. The scarcity of funding contributes decisively to the inconclusiveness of the vaccine development. The data summarized here intends to highlight the necessity to improve the current knowledge of this neglected retrovirus, encouraging for more studies on vaccine development aiming the to eliminate this human threat.
https://www.crd.york.ac.uk/prospero, identifier (CRD42021270412).
UNASSIGNED:本审查遵循系统审查和荟萃分析的首选报告项目(PRISMA®)指南,并在国际前瞻性系统审查注册中心(PROSPERO)注册。
UNASSIGNED:对这些文章的分析表明,正在开发的潜在疫苗设计是可用的,
UNASSIGNED:尽管HTLV-1在40年前就被发现了,
UNASSIGNED:https://www。