METHODS: In this randomized clinical trial (ClinicalTrials.gov ID: NCT05039502), seventy-five patients scheduled for retreatment were randomly divided into 3 groups according to the file system used to remove root canal filling materials (n = 25): PTUR, RB, and DR + XPFR. After reshaping and disinfection of the root canals, periapical fluid samples were taken, and the levels of Substance P, CGRP, IL-6, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) test. Data were analyzed using the Kruskal-Wallis and chi-square tests. The level of significance was set as p = 0. 05.
RESULTS: All the allocated participants received the intervention and were analyzed. There was no statistically significant difference among groups in terms of gender, age, tooth localization, and the distribution of analgesic use after treatment (p values 0.799, 0.095, 0.637, 1.000, respectively). No statistically significant difference was found in terms of the levels of Substance P, CGRP, and IL-10 among groups (p > .05), except IL-6.
CONCLUSIONS: PTUR, RB, and DR + XPFR files have comparable results in the expression of inflammatory mediators.
CONCLUSIONS: Retreatment files powered with rotary or reciprocating motion produced similar neuropeptide and cytokine levels in patients.
方法:在这项随机临床试验中(ClinicalTrials.govID:NCT05039502),根据用于清除根管充填材料的文件系统,将75例计划进行再治疗的患者随机分为3组(n=25):PTUR,RB,和DR+XPFR。根管重塑和消毒后,采集根尖周液体样本,和物质P的水平,CGRP,采用酶联免疫吸附试验(ELISA)检测IL-6和IL-10。使用Kruskal-Wallis和卡方检验分析数据。显著性水平设定为p=0。05.
结果:所有分配的参与者都接受了干预并进行了分析。在性别方面,组间没有统计学上的显著差异,年龄,牙齿定位,和治疗后镇痛药使用的分布(p值分别为0.799、0.095、0.637、1.000)。P物质水平无统计学差异,CGRP,各组间IL-6和IL-10(p>0.05)。
结论:PTUR,RB,和DR+XPFR文件在炎症介质的表达方面具有相当的结果。
结论:以旋转或往复运动为动力的复诊在患者中产生相似的神经肽和细胞因子水平。