PDF(Pubmed)
Abstract：
UNASSIGNED: Colorectal cancer (CRC) is the 3rd most common malignant tumors after breast cancer and lung cancer, accounting for 9.4% of patients. Some patients had distant metastasis at the time of diagnosis without surgery opportunity. It is particularly important to prolong patient survival and improve quality of life.
UNASSIGNED: A 73-year-old female was admitted with discomfort over 2 months. Enlarged lymph nodes in the left supraclavicular fossa were observed in chest computed tomography (CT). Enhanced abdominal CT showed thickening of the right colon wall with multiple metastatic lymph nodes in the abdomen. Colonoscopy showed ileocecal mass and pathology showed moderately and poorly differentiated adenocarcinoma. Physical examination showed a 2*2 cm lymph node could be touched in the left supraclavicular fossa. The patient was diagnosed advanced colon cancer by the histopathological examination and imaging findings. Actually, it is hardly to resect radically.
UNASSIGNED: Sintilimab combined with XELOX was initiated. Two period of treatment after initial therapy, laparoscopic radical resection of right colon cancer was performed successfully.
UNASSIGNED: After conversion treatment, the enlarged lymph nodes and primary tumor were significantly reduced. The patient was discharged successfully three weeks after surgery. Both specimen and 14 lymph nodes dissected showed no malignancy in pathology. Tumor regression grading (TRG) is 0, which indicate complete regression with no residual tumor cells including lymph nodes. The patient obtained a pathological complete response (pCR).
UNASSIGNED: The patient achieved a great therapeutic benefit with the above-mentioned chemotherapy in this case. The case provides a potential reference for pMMR CRC patients treating with immune checkpoint inhibitors (ICIs).
UNASSIGNED: A 73-year-old female was admitted with discomfort over 2 months. Enlarged lymph nodes in the left supraclavicular fossa were observed in chest computed tomography (CT). Enhanced abdominal CT showed thickening of the right colon wall with multiple metastatic lymph nodes in the abdomen. Colonoscopy showed ileocecal mass and pathology showed moderately and poorly differentiated adenocarcinoma. Physical examination showed a 2*2 cm lymph node could be touched in the left supraclavicular fossa. The patient was diagnosed advanced colon cancer by the histopathological examination and imaging findings. Actually, it is hardly to resect radically.
UNASSIGNED: Sintilimab combined with XELOX was initiated. Two period of treatment after initial therapy, laparoscopic radical resection of right colon cancer was performed successfully.
UNASSIGNED: After conversion treatment, the enlarged lymph nodes and primary tumor were significantly reduced. The patient was discharged successfully three weeks after surgery. Both specimen and 14 lymph nodes dissected showed no malignancy in pathology. Tumor regression grading (TRG) is 0, which indicate complete regression with no residual tumor cells including lymph nodes. The patient obtained a pathological complete response (pCR).
UNASSIGNED: The patient achieved a great therapeutic benefit with the above-mentioned chemotherapy in this case. The case provides a potential reference for pMMR CRC patients treating with immune checkpoint inhibitors (ICIs).
摘要：
未经授权：结直肠癌（CRC）是仅次于乳腺癌和肺癌的第三大常见恶性肿瘤，占患者的9.4%。一些患者在诊断时发生远处转移，没有手术机会。延长患者生存期和提高生活质量尤为重要。
未经评估：一名73岁女性因2个月以上的不适入院。在胸部计算机断层扫描（CT）中观察到左侧锁骨上窝的肿大淋巴结。增强腹部CT显示右结肠壁增厚，腹部多发转移淋巴结。结肠镜检查显示回盲部肿块，病理显示中、低分化腺癌。体格检查显示左侧锁骨上窝可触及2*2cm淋巴结。通过组织病理学检查和影像学发现，患者被诊断为晚期结肠癌。事实上,很难彻底切除。
未经批准：Sintilimab与XELOX联合使用。初始治疗后两个疗程，腹腔镜右半结肠癌根治术成功。
UNASSIGNED：转换处理后，肿大的淋巴结和原发肿瘤明显减少。术后3周患者顺利出院。标本和解剖的14个淋巴结均未见病理恶性。肿瘤消退分级(TRG)为0,其指示完全消退,没有包括淋巴结的残留肿瘤细胞。患者获得病理完全缓解(pCR)。
UNASSIGNED：在这种情况下，患者通过上述化学疗法获得了巨大的治疗益处。该病例为使用免疫检查点抑制剂（ICIs）治疗pMMRCRC患者提供了潜在参考。
未经评估：一名73岁女性因2个月以上的不适入院。
未经批准：Sintilimab与XELOX联合使用。
UNASSIGNED：转换处理后，
UNASSIGNED：在这种情况下，患者通过上述化学疗法获得了巨大的治疗益处。
