Abstract：
Considering that vaccination with yellow fever vaccine (YFV) is the most important method to prevent and control yellow fever (YF), this study synthesized evidence on factors associated with YFV failure.
A systematic review (SR) was performed in the PubMed, Cochrane CENTRAL, Embase, and LILACS databases up to November 2019. Observational and experimental analytical epidemiological studies that analyzed the failure of YFV were included. This review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and meta-Analyses.
A total of 1,466 articles were identified after searching the databases of which 46 were included in the qualitative analysis after applying the elegibility criteria. Our findings indicated that YFV confers protective immunity in different age groups; when produced by different producers; when administered simultaneously with a range of other vaccines; when used as fractional doses and when used with prophylactic and immunosuppressive therapies. It failed to produce a protective response in some pregnant women, children under two years of age, children with Kwashiorkor and when long periods of time have passed after vaccination. For individuals with human immunodeficiency virus (HIV), the results were divergent.
The results of this SR revealed the factors associated with the failure of the YFV, and the results can support recommendations on vaccination policies, support the safety of health professionals who work directly with immunization in the implementation of the vaccination schedule, in addition to guiding future research and enhance the credibility of YFV in the prevention of a serious disease such as YF.
A systematic review (SR) was performed in the PubMed, Cochrane CENTRAL, Embase, and LILACS databases up to November 2019. Observational and experimental analytical epidemiological studies that analyzed the failure of YFV were included. This review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and meta-Analyses.
A total of 1,466 articles were identified after searching the databases of which 46 were included in the qualitative analysis after applying the elegibility criteria. Our findings indicated that YFV confers protective immunity in different age groups; when produced by different producers; when administered simultaneously with a range of other vaccines; when used as fractional doses and when used with prophylactic and immunosuppressive therapies. It failed to produce a protective response in some pregnant women, children under two years of age, children with Kwashiorkor and when long periods of time have passed after vaccination. For individuals with human immunodeficiency virus (HIV), the results were divergent.
The results of this SR revealed the factors associated with the failure of the YFV, and the results can support recommendations on vaccination policies, support the safety of health professionals who work directly with immunization in the implementation of the vaccination schedule, in addition to guiding future research and enhance the credibility of YFV in the prevention of a serious disease such as YF.
摘要：
背景：考虑到用黄热病疫苗（YFV）接种疫苗是预防和控制黄热病（YF）的最重要方法，这项研究综合了与YFV失效相关因素的证据。
方法：在PubMed，科克伦中部,Embase,以及截至2020年11月的LILACS数据库。包括分析YFV失败的观察和实验分析流行病学研究。本审查遵循了系统审查和荟萃分析的首选报告项目指南。
结果：在检索数据库后，共鉴定出1,466篇文章，其中46篇在应用合格性标准后被纳入定性分析。我们的发现表明，YFV在不同年龄段赋予保护性免疫力；当由不同生产者生产时；当与一系列其他疫苗同时施用时；当与预防性和免疫抑制疗法一起使用时，作为分剂量使用时；它未能在一些孕妇中产生保护性反应，两岁以下的儿童，患有Kwashiorkor的儿童以及接种疫苗后长时间过去的儿童。对于患有人类免疫缺陷病毒（HIV）的个体，结果大相径庭。
结论：此SR的结果揭示了与YFV失效相关的因素，结果可以支持有关疫苗接种政策的建议，支持在实施疫苗接种计划时直接从事免疫工作的卫生专业人员的安全，除了指导未来的研究和提高YFV在预防YF等严重疾病中的可信度。
方法：在PubMed，
结果：在检索数据库后，共鉴定出1,466篇文章，其中46篇在应用合格性标准后被纳入定性分析。
结论：此SR的结果揭示了与YFV失效相关的因素，
