PDF(Pubmed)
Abstract：
There is scarce evidence about early nutrition programming of dynamic aspects of glucose homeostasis. We analyzed the long-term effects of early nutrition on glycemic variability in healthy children. A total of 92 children participating in the COGNIS study were considered for this analysis, who were fed with: a standard infant formula (SF, n = 32), an experimental formula (EF, n = 32), supplemented with milk fat globule membrane (MFGM) components, long-chain polyunsaturated fatty acids (LC-PUFAs), and synbiotics, or were breastfed (BF, n = 28). At 6 years old, BF children had lower mean glucose levels and higher multiscale sample entropy (MSE) compared to those fed with SF. No differences in MSE were found between EF and BF groups. Normal and slow weight gain velocity during the first 6 months of life were associated with higher MSE at 6 years, suggesting an early programming effect against later metabolic disorders, thus similarly to what we observed in breastfed children. Conclusion: According to our results, BF and normal/slow weight gain velocity during early life seem to protect against glucose homeostasis dysregulation at 6 years old. EF shows functional similarities to BF regarding children\'s glucose variability. The detection of glucose dysregulation in healthy children would help to develop strategies to prevent the onset of metabolic disorders in adulthood.
摘要：
关于葡萄糖稳态的动态方面的早期营养规划的证据很少。我们分析了早期营养对健康儿童血糖变异性的长期影响。共有92名参与COGNIS研究的儿童被考虑进行这项分析，喂食：标准婴儿配方奶粉(SF，n=32),实验公式(EF，n=32),补充乳脂球膜（MFGM）成分，长链多不饱和脂肪酸（LC-PUFA），和合生元，或母乳喂养(BF，n=28）。6岁时,与用SF喂养的儿童相比，BF儿童的平均葡萄糖水平较低，多尺度样本熵（MSE）较高。EF和BF组之间的MSE没有差异。在生命的前6个月中，正常和缓慢的体重增加速度与6岁时较高的MSE相关。表明对后期代谢紊乱的早期编程效应，因此与我们在母乳喂养儿童中观察到的情况相似。结论：根据我们的结果，生命早期的BF和正常/缓慢的体重增加速度似乎可以防止6岁时的葡萄糖稳态失调。EF与BF在儿童血糖变异性方面表现出功能相似性。在健康儿童中检测葡萄糖失调将有助于制定预防成年期代谢紊乱发作的策略。
