Abstract：
Background and Objectives: The purpose of this study was to evaluate the impact of surgical and conservative, non-surgical treatment on general health-related (QoL) and oral health-related quality of life (OHRQoL) in patients suffering from AAOMS stage I MRONJ. Materials and Methods: In the course of this prospective clinical study, QoL and OHRQoL using QLQ-C30 and QHIP G14 questionnaire were longitudinally assessed in N = 174 prospectively enrolled patients with indication of treatment of MRONJ stage I over a period of 12 months. Patients received conservative or surgical treatment. The measurement time points were preoperatively (T0), 12 weeks (T1), 6 months (T2) and 1 year after operation (T3). Results: For OHRQoL, no significant (p > 0.05) differences were found between both treatment groups for all timepoints (T0-T3). In the surgical treatment group, OHIP scores of T1, T2 and T3 were significantly lower than baseline measures (T0) (T0-T1 (2.99, p = 0.024), T0-T2 (5.20, p < 0.001), T0-T3 (7.44, p < 0.001)). For conservative treatment group OHIP, scores of T2 and T3 were significantly lower than baseline measures (T0) (T0-T2 (9.09, p = 0.013), T0-T3 (12.79, p < 0.001)). There was no statistically significant effect of time on QLQ-C30 scores in both groups (surgical treatment: F(3, 174) = 1.542, p < 0.205, partial η2 = 0.026; conservative treatment: F(3, 30) = 0.528, p = 0.667, partial η2 = 0.050). QLQ-C30 scores turned out to be significantly lower in the non-surgical group at T1 (p = 0.036) and T3 (p = 0.047) compared to the surgical treatment group. Conclusions: Surgical and conservative treatment of MRONJ stage I significantly improves patients\' OHRQoL. Surgical treatment is superior to conservative treatment of MRONJ stage I regarding general QoL. Therefore, surgical treatment of MRONJ stage I should not be omitted for QoL reasons.
摘要：
背景和目的：本研究的目的是评估手术和保守治疗的影响，AAOMSI期MRONJ患者的一般健康相关（QoL）和口腔健康相关生活质量（OHRQoL）的非手术治疗。材料和方法：在这项前瞻性临床研究的过程中，使用QLQ-C30和QHIPG14问卷的QoL和OHRQoL在12个月内对174例前瞻性招募的具有MRONJI期治疗指征的患者进行纵向评估。患者接受保守或手术治疗。测量时间点是术前(T0)，12周（T1），术后6个月(T2)和1年(T3)。结果：对于OHRQoL，对于所有时间点(T0-T3),两个治疗组之间没有发现显著差异(p>0.05)。在手术治疗组中，T1，T2和T3的OHIP评分显着低于基线测量值（T0）（T0-T1（2.99，p=0.024），T0-T2（5.20，p<0.001），T0-T3(7.44,p<0.001))。保守治疗组OHIP,T2和T3的得分明显低于基线测量值（T0）（T0-T2（9.09，p=0.013），T0-T3(12.79,p<0.001))。两组时间对QLQ-C30评分无统计学意义(手术治疗:F(3,174)=1.542,p<0.205,部分η2=0.026;保守治疗:F(3,30)=0.528,p=0.667,部分η2=0.050)。与手术治疗组相比，非手术组的T1（p=0.036）和T3（p=0.047）的QLQ-C30评分显着降低。结论：MRONJI期的手术和保守治疗显着改善了OHRQoL患者。就一般QoL而言，MRONJI期的手术治疗优于保守治疗。因此,由于QoL原因，不应省略MRONJI期的手术治疗。
