Abstract：
The ethylene-responsive element binding factor-associated amphiphilic repression (EAR) motif, defined by the consensus sequence patterns LxLxL or DLNx(x)P, is found in a diverse range of plant species. It is the most predominant form of active transcriptional repression motif identified so far in plants. Despite its small size (5 to 6 amino acids), the EAR motif is primarily involved in the negative regulation of developmental, physiological and metabolic functions in response to abiotic and biotic stresses. Through an extensive literature review, we identified 119 genes belonging to 23 different plant species that contain an EAR motif and function as negative regulators of gene expression in various biological processes, including plant growth and morphology, metabolism and homeostasis, abiotic stress response, biotic stress response, hormonal pathways and signalling, fertility, and ripening. Positive gene regulation and transcriptional activation are studied extensively, but there remains much more to be discovered about negative gene regulation and the role it plays in plant development, health, and reproduction. This review aims to fill the knowledge gap and provide insights into the role that the EAR motif plays in negative gene regulation, and provoke further research on other protein motifs specific to repressors.
摘要：
乙烯响应元件结合因子相关的两亲性抑制（EAR）基序，由共有序列模式LxLxL或DLNx(x)P定义，存在于各种各样的植物物种中。它是迄今为止在植物中鉴定的活性转录抑制基序的最主要形式。尽管它的小尺寸（5至6个氨基酸），EAR基序主要参与发育的负调控，响应非生物和生物胁迫的生理和代谢功能。通过广泛的文献综述，我们确定了119个基因，属于23种不同的植物物种，其中包含EAR基序，并在各种生物过程中充当基因表达的负调节因子。包括植物生长和形态，新陈代谢和体内平衡，非生物应激反应，生物应激反应，荷尔蒙通路和信号，生育力,和成熟。正基因调控和转录激活被广泛研究，但是关于负基因调控及其在植物发育中的作用，还有更多的发现，健康,和繁殖。这篇综述旨在填补知识空白，并提供有关EAR基序在负基因调控中的作用的见解。并引发了对其他抑制因子特异性蛋白质基序的进一步研究。
