关键词: Fournier’s gangrene antibiotic stewardship necrotizing fasciitis outcome parameters sepsis

来  源:   DOI:10.3390/antibiotics12020197

Abstract:
BACKGROUND: Fournier\'s gangrene (FG) is a life-threatening, necrotizing infection. Due to the rareness of the disease, it is challenging to plan robust prospective studies. This study aims to describe current practice patterns of FG in Europe and identify implications for planning a prospective FG registry.
METHODS: Online non-validated 17-items survey among urologists treating FG in in European hospitals. Questionnaires were analyzed with LimeSurvey (LimeSurvey GmbH Hamburg, Germany).
RESULTS: 229 responses from ten different European countries were submitted, and 117 (51.1%) urologists completed the questionnaire. The departments treat a mean of 4.2 (SD 3.11) patients per year. The urology department mostly takes the lead in treating FG patients (n = 113; 96.6%). The practice in FG is very heterogenic and mostly case-based all over Europe, e.g., vacuum-assisted wound closure (VAC) is mostly used (n = 50; 42.7%) as adjunct wound. The biggest challenges in FG are the short time to diagnosis and treatment, standardization and establishment of guidelines, and disease awareness. Additionally, participants stated that an international registry is an outstanding initiative, and predictive models are needed.
CONCLUSIONS: There is no standard of care in the diagnosis, treatment, and long-term care of FG all over Europe. Further research could be conducted with a prospective registry.
摘要:
背景:Fournier坏疽(FG)是一种危及生命的坏疽,坏死性感染。由于这种疾病的稀缺性,规划稳健的前瞻性研究具有挑战性.本研究旨在描述欧洲FG的当前实践模式,并确定对计划前瞻性FG注册的影响。
方法:在欧洲医院治疗FG的泌尿科医师中进行的在线非验证17项调查。问卷用LimeSurvey(LimeSurveyGmbH汉堡,德国)。
结果:提交了来自十个不同欧洲国家的229份回复,117名(51.1%)泌尿科医生完成了问卷。科室每年平均治疗4.2(SD3.11)名患者。泌尿科主要率先治疗FG患者(n=113;96.6%)。FG的实践是非常异质的,并且在整个欧洲都是基于案例的,例如,真空辅助伤口闭合(VAC)主要用作辅助伤口(n=50;42.7%)。FG最大的挑战是诊断和治疗时间短,标准化和准则的建立,和疾病意识。此外,与会者指出,国际登记册是一项杰出的举措,和预测模型是必要的。
结论:诊断中没有标准的护理,治疗,以及欧洲各地FG的长期护理。可以通过前瞻性注册表进行进一步的研究。
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