Amorphous calcium phosphate, the lack of order is an abundance of possibilities.

无定形磷酸钙,缺乏秩序是一种丰富的可能性。

• 发表时间: Mar 2022
• 来源期刊: Biomater Biosyst
• DOI: 10.1016/j.bbiosy.2021.100037
• PMID: 36825112
• 文章类型: Journal Article
• 作者列表: Degli Esposti L,Iafisco M

关键词: ACP, Amorphous calcium phosphate; Amorphous calcium phosphates; Biomimetics; Bone cements; CPP, Casein phosphopeptide; CaP, Calcium phosphate; Coatings; Dental remineralization; Drug delivery

Abstract

For almost three decades from its discovery, amorphous calcium phosphate (ACP) was not considered a suitable biomaterial due to its structural instability. Thanks to its unique properties in respect to crystalline calcium phosphate phases, nowadays ACP is used in promising devices for hard tissue regeneration. Here we have highlighted the features of ACP that were harnessed to create excellent biomaterials for dental remineralization, self-setting bone cements, drug delivery, and coatings of prostheses. Its current limitations as well as future perspectives of development were concisely described. Despite more research works are needed, we envisage that the future of ACP is bright.

摘要

自发现以来近三十年，无定形磷酸钙（ACP）由于其结构不稳定性而不被认为是合适的生物材料。由于其在结晶磷酸钙相方面的独特性质，如今，ACP已用于有前途的硬组织再生装置中。在这里，我们强调了ACP的特征，这些特征被用来创造用于牙科再矿化的优秀生物材料，自凝固骨水泥，药物输送,和假体涂层。简要描述了其当前的局限性以及未来的发展前景。尽管需要更多的研究工作，我们设想ACP的未来是光明的。