PDF(Pubmed)
Abstract：
Nuclear factor-kappa B (NF-κB) pathways have a close relationship with many diseases, especially in terms of the regulation of inflammation and the immune response. Non-coding RNAs (ncRNAs) are a heterogeneous subset of endogenous RNAs that directly affect cellular function in the absence of proteins or peptide products; these include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), etc. Studies on the roles of ncRNAs in targeting the NF-κB pathways in aquatic animals are scarce. A few research studies have confirmed detailed regulatory mechanisms among ncRNAs and the NF-κB pathways in aquatic animals. This comprehensive review is presented concerning ncRNAs targeting the NF-κB pathway in aquatic animals and provides new insights into NF-κB pathways regulatory mechanisms of aquatic animals. The review discusses new possibilities for developing non-coding-RNA-based antiviral applications in fisheries.
摘要：
核因子-κB(NF-κB)通路与多种疾病有着密切的关系,特别是在炎症和免疫反应的调节方面。非编码RNA（ncRNA）是内源性RNA的异质子集，在不存在蛋白质或肽产物的情况下直接影响细胞功能；这些包括microRNA（miRNA），长链非编码RNA（lncRNA），环状RNA（circularRNAs），等。关于ncRNAs在水生动物中靶向NF-κB途径中的作用的研究很少。一些研究已经证实了水生动物中ncRNAs和NF-κB通路之间的详细调控机制。本文综述了针对水生动物NF-κB通路的ncRNAs，并为水生动物NF-κB通路调控机制提供了新的见解。该评论讨论了在渔业中开发基于非编码RNA的抗病毒应用的新可能性。
