Abstract：
Testis tumors are uncommon in oncology, and testicular metastasis from distant solid tumors are even rarer. We present two cases encountered in our department of pathology in CHU de Rennes, France. Moreover, we collected all reported cases in the Medline/PubMed databases of non-hematopoietic secondary testis tumors in adults, excluding autopsy studies, to propose an integrative study on this topic. In total, we report 98 cases of secondary testis lesions to prostate (n=38, 38.77 %), colorectal (n=19, 19.39%), gastric (n=12, 12.24%), kidney (n=7, 7.14%), lung (n=6, 6.12%) and other primary cancers. The median age at diagnosis was 66.5 years. We identified significantly more prostate adenocarcinoma (P<0.0001) when the primary tumor was known and significantly more colorectal adenocarcinoma (P=0.035) and pancreatic adenocarcinoma (P=0.002) when the primary tumor was unknown. The age at diagnosis was older when the primary tumor was known (P=0.007). We present the challenges for the diagnosis and propose some elements for diagnosis orientation. Finally, we discuss the possible ways of metastatic dissemination from primary site to testis, as illustrated by the two cases we present.
摘要：
睾丸肿瘤在肿瘤学中并不常见，远处实体瘤的睾丸转移更罕见。我们介绍了我们在CHUdeRennes的病理科遇到的两个病例，法国。此外，我们在Medline/PubMed数据库中收集了成人非造血继发性睾丸肿瘤的所有报告病例，不包括尸检研究,提出关于这一主题的综合研究。总的来说,我们报告了98例继发性前列腺睾丸病变（n=38，38.77％），结直肠(n=19，19.39%)，胃（n=12，12.24%），肾（n=7，7.14%），肺癌（n=6，6.12%）和其他原发癌。诊断时的中位年龄为66.5岁。当原发性肿瘤已知时，我们发现明显更多的前列腺腺癌（P<0.0001），当原发性肿瘤未知时，明显更多的结肠直肠腺癌（P=0.035）和胰腺腺癌（P=0.002）。已知原发肿瘤时，诊断年龄较大（P=0.007）。我们提出了诊断的挑战，并提出了一些诊断方向的要素。最后,我们讨论了从原发部位转移到睾丸的可能途径，正如我们介绍的两种情况所说明的那样。
