关键词: Alkaptonuria multiple autoimmune syndrome polyautoimmunity scleritis sclerouveitis uveitis

Mesh : Humans Female Aged Alkaptonuria / diagnosis complications Scleritis / diagnosis etiology drug therapy Sjogren's Syndrome / diagnosis complications Hashimoto Disease / diagnosis complications Autoimmune Diseases / diagnosis complications

来  源:   DOI:10.1080/09273948.2023.2179498

Abstract:
UNASSIGNED: To present a novel association of multiple autoimmune syndrome (MAS) in a patient with sclerouveitis and alkaptonuria.
UNASSIGNED: A 68-year-old female with alkaptonuria, Hashimoto\'s thyroiditis, and familial autoimmunity presented with decreased VA, red eye, foreign body sensation, and ocular pain. Ophthalmological examination: OD conjunctival hyperemia, ochronosis, a reddish-violet scleral nodule, keratic precipitates, 2+ cells in the anterior chamber, 0.5+ vitreous cells, and mild vitreous haze. The patient was diagnosed with anterior uveitis and anterior nodular scleritis. Due to the associated sicca symptoms, a salivary gland biopsy was ordered, confirming Sjögren\'s syndrome. Then, MAS was diagnosed, and immunomodulatory medications were started; however, as she was refractory to more than two of them, it was suggested to start biological treatment.
UNASSIGNED: We present a novel MAS-type 2 pattern consisting of Hashimoto\'s thyroiditis, sclerouveitis, and Sjögren\'s syndrome. Its diagnosis and management represent a challenge, so a multidisciplinary approach should be provided.
摘要:
未经批准:在患有硬膜炎和碱蛋白尿的患者中呈现一种新的多重自身免疫综合征(MAS)的关联。
未经批准:一名68岁女性,桥本甲状腺炎,和家族性自身免疫表现为VA降低,红眼,异物感,和眼部疼痛。眼科检查:OD结膜充血,慢性疾病,红紫色巩膜结节,角质沉淀物,前房2+细胞,0.5+玻璃体细胞,和轻微的玻璃体雾霾。患者被诊断为前葡萄膜炎和前结节性巩膜炎。由于相关的干燥症状,做了唾液腺活检,确认Sjögren综合征。然后,MAS被诊断出来,和免疫调节药物开始;然而,因为她对其中两个以上的人很难接受,建议开始生物治疗。
未经授权:我们提出了一种由桥本甲状腺炎组成的新型MAS2型模式,巩膜炎,和干燥综合征。它的诊断和管理是一个挑战,所以应该提供多学科的方法。
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