{Reference Type}: Case Reports
{Title}: Sclerouveitis as Part of Multiple Autoimmune Syndrome in a Patient with Alkaptonuria: A Case Report.
{Author}: Cifuentes-González C;Rojas-Carabali W;Sierra-Cote MC;de-la-Torre A;
{Journal}: Ocul Immunol Inflamm
{Volume}: 32
{Issue}: 5
{Year}: Jul 2024 23
{Factor}: 3.728
{DOI}: 10.1080/09273948.2023.2179498
{Abstract}: <B>UNASSIGNED: </B>To present a novel association of multiple autoimmune syndrome (MAS) in a patient with sclerouveitis and alkaptonuria.<BR><B>UNASSIGNED: </B>A 68-year-old female with alkaptonuria, Hashimoto's thyroiditis, and familial autoimmunity presented with decreased VA, red eye, foreign body sensation, and ocular pain. Ophthalmological examination: OD conjunctival hyperemia, ochronosis, a reddish-violet scleral nodule, keratic precipitates, 2+ cells in the anterior chamber, 0.5+ vitreous cells, and mild vitreous haze. The patient was diagnosed with anterior uveitis and anterior nodular scleritis. Due to the associated sicca symptoms, a salivary gland biopsy was ordered, confirming Sjögren's syndrome. Then, MAS was diagnosed, and immunomodulatory medications were started; however, as she was refractory to more than two of them, it was suggested to start biological treatment.<BR><B>UNASSIGNED: </B>We present a novel MAS-type 2 pattern consisting of Hashimoto's thyroiditis, sclerouveitis, and Sjögren's syndrome. Its diagnosis and management represent a challenge, so a multidisciplinary approach should be provided.