Abstract：
The aim of this study was to prospectively evaluate the olfactory function in a series of individuals infected with SARS-CoV-2 and who had undergone psychophysical olfactory assessment prior to infection. Individuals unexposed to SARS-CoV-2 infection underwent a psychophysical evaluation of smell with the Sniffin\' Sticks test. The subjects were followed prospectively and included in the study if they developed SARS-CoV-2 infection with a second test 60 days after recovery. At the 60-day follow-up of the 41 included subjects, 2 (4.9%) self-reported persistent olfactory dysfunction (OD). The differences between TDI scores before and after infection were statistically significant (37 [interquartile range (IQR), 34.25-39.25] vs 34.75 [IQR, 32.25-38]; p = .021). Analyzing the individual olfactory domains, the differences were significant for threshold (T) (9.75 [IQR, 9-11.25] vs 8.25 [IQR, 7.25-10.25]; p = .009) but not for odor discrimination (D) (p = .443) and identification (I) (p = .159). SARS-CoV-2 causes a significant reduction in the olfactory function, in particular affecting the olfactory threshold, even in subjects who do not self-report an OD.
摘要：
这项研究的目的是前瞻性评估一系列感染SARS-CoV-2并在感染前进行了心理物理嗅觉评估的个体的嗅觉功能。未暴露于SARS-CoV-2感染的个体通过Sniffin\'Sticks测试对气味进行了心理物理评估。对受试者进行前瞻性随访，如果他们在康复后60天进行第二次测试，则将其纳入研究。在纳入的41名受试者的60天随访中，2（4.9％）自我报告的持续性嗅觉功能障碍（OD）。感染前后TDI评分差异有统计学意义(37[四分位距(IQR),34.25-39.25]vs34.75[IQR，32.25-38]；p=.021）。分析各个嗅觉领域，阈值(T)(9.75[IQR，9-11.25]vs8.25[IQR，7.25-10.25];p=.009），但不适用于气味辨别（D）（p=.443）和识别（I）（p=.159）。SARS-CoV-2导致嗅觉功能显著降低，特别是影响嗅觉阈值，即使在没有自我报告OD的受试者中。
