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Abstract：
Bone and soft tissue sarcomas are rare tumors and extremely rarely metastasize to the brain. Previous studies have examined the characteristics and poor prognostic factors in cases of sarcoma brain metastasis (BM). Due to the rarity of cases of BM from sarcoma, limited data exist concerning the prognostic factors and treatment strategies.
A retrospective single-center study was performed on sarcoma patients with BM. The clinicopathological characteristics and treatment options for BM of sarcoma were investigated to identify predictive prognostic factors.
Between 2006 and 2021, 32 patients treated for newly diagnosed BM at our hospital were retrieved among 3133 bone and soft tissue sarcoma patients via our database. The most common symptom was headache (34%), and the most common histological subtypes were alveolar soft part sarcoma (ASPS) and undifferentiated pleomorphic sarcoma (25%). Non-ASPS (p = 0.022), presence of lung metastasis (p = 0.046), a short duration between initial metastasis, and the diagnosis of brain metastasis (p = 0.020), and the absence of stereotactic radiosurgery for BM (p = 0.0094) were significantly correlated with a poor prognosis.
In conclusion, the prognosis of patients with brain metastases of sarcomas is still dismal, but it is necessary to be aware of the factors associated with a relatively favorable prognosis and to select treatment options appropriately.
A retrospective single-center study was performed on sarcoma patients with BM. The clinicopathological characteristics and treatment options for BM of sarcoma were investigated to identify predictive prognostic factors.
Between 2006 and 2021, 32 patients treated for newly diagnosed BM at our hospital were retrieved among 3133 bone and soft tissue sarcoma patients via our database. The most common symptom was headache (34%), and the most common histological subtypes were alveolar soft part sarcoma (ASPS) and undifferentiated pleomorphic sarcoma (25%). Non-ASPS (p = 0.022), presence of lung metastasis (p = 0.046), a short duration between initial metastasis, and the diagnosis of brain metastasis (p = 0.020), and the absence of stereotactic radiosurgery for BM (p = 0.0094) were significantly correlated with a poor prognosis.
In conclusion, the prognosis of patients with brain metastases of sarcomas is still dismal, but it is necessary to be aware of the factors associated with a relatively favorable prognosis and to select treatment options appropriately.
摘要：
背景：骨和软组织肉瘤是罕见的肿瘤，很少转移到大脑。先前的研究已经检查了肉瘤脑转移（BM）病例的特征和不良预后因素。由于来自肉瘤的BM病例很少，关于预后因素和治疗策略的数据有限。
方法：对BM肉瘤患者进行回顾性单中心研究。研究了肉瘤BM的临床病理特征和治疗方案，以确定预测预后因素。
结果：在2006年至2021年之间，通过我们的数据库从3133名骨和软组织肉瘤患者中检索到了在我们医院接受新诊断的BM治疗的32例患者。最常见的症状是头痛（34%）。最常见的组织学亚型是肺泡软组织肉瘤（ASPS）和未分化多形性肉瘤（25％）。非ASPS（p=0.022），存在肺转移（p=0.046），初始转移之间的持续时间很短，和脑转移的诊断（p=0.020），并且缺乏立体定向放射外科治疗BM（p=0.0094）与不良预后显着相关。
结论：结论：肉瘤脑转移患者的预后仍然不佳，但有必要了解与相对良好预后相关的因素，并适当选择治疗方案。
方法：对BM肉瘤患者进行回顾性单中心研究。
结果：在2006年至2021年之间，通过我们的数据库从3133名骨和软组织肉瘤患者中检索到了在我们医院接受新诊断的BM治疗的32例患者。
结论：结论：
