Abstract:
Salivary gland hypofunction and xerostomia following pathological conditions like Sjogren\'s syndrome or head and neck radiotherapy usually lead to tremendous impairment of oral health, speech, and swallowing. The use of systemic drugs to alleviate the symptoms of these conditions has been associated with various adverse effects. Techniques of local drug delivery to the salivary gland have grown enormously to address this problem properly. The techniques include intraglandular and intraductal injections. In this chapter, we will provide a review of the literature for both techniques while incorporating our lab experience in using them.
摘要:
如干燥综合征或头颈部放疗等病理条件下的唾液腺功能减退和口干症通常会导致口腔健康的巨大损害,演讲,和吞咽。使用全身性药物来缓解这些病症的症状与各种不良反应有关。局部药物递送到唾液腺的技术已经得到了极大的发展,以适当地解决这个问题。该技术包括颗粒内和导管内注射。在这一章中,我们将对这两种技术的文献进行回顾,同时结合我们在使用它们方面的实验室经验。