Abstract：
Most of studies relating ambient nitrogen dioxide (NO2) exposure to hospital admissions for cardiovascular diseases (CVDs) were conducted among urban population. Whether and to what extent these results could be generalizable to rural population remains unknown. We addressed this question using data from the New Rural Cooperative Medical Scheme (NRCMS) in Fuyang, Anhui, China. Daily hospital admissions for total CVDs, ischaemic heart disease, heart failure, heart rhythm disturbances, ischaemic stroke, and haemorrhagic stroke in rural regions of Fuyang, China, were extracted from NRCMS between January 2015 and June 2017. A two-stage time-series analysis method was used to assess the associations between NO2 and CVD hospital admissions and the disease burden fractions attributable to NO2. In our study period, the average number (standard deviation) of hospital admissions per day were 488.2 (117.1) for total CVDs, 179.8 (45.6) for ischaemic heart disease, 7.0 (3.3) for heart rhythm disturbances, 13.2 (7.2) for heart failure, 267.9 (67.7) for ischaemic stroke, and 20.2 (6.4) for haemorrhagic stroke. The 10-μg/m3 increase of NO2 was related to an elevated risk of 1.9% (RR: 1.019, 95% CI: 1.005 to 1.032) for hospital admissions of total CVDs at lag0-2 days, 2.1% (1.021, 1.006 to 1.036) for ischaemic heart disease, and 2.1% (1.021, 1.006 to 1.035) for ischaemic stroke, respectively, while no significant association was observed between NO2 and hospital admissions for heart rhythm disturbances, heart failure, and haemorrhagic stroke. The attributable fractions of total CVDs, ischaemic heart disease, and ischaemic stroke to NO2 were 6.52% (1.87 to 10.94%), 7.31% (2.19 to 12.17%), and 7.12% (2.14 to 11.85%), respectively. Our findings suggest that CVD burdens in rural population are also partly attributed to short-term exposure to NO2. More studies across rural regions are required to replicate our findings.
摘要：
大多数与环境二氧化氮（NO2）暴露于心血管疾病（CVD）住院有关的研究都是在城市人群中进行的。这些结果是否以及在多大程度上可以推广到农村人口仍然未知。我们使用阜阳新型农村合作医疗计划（NRCMS）的数据解决了这个问题，安徽,中国。总心血管疾病的每日住院人数，缺血性心脏病,心力衰竭,心律紊乱,缺血性中风,阜阳农村出血性中风，中国,在2015年1月至2017年6月之间从NCMS提取。使用两阶段时间序列分析方法来评估NO2和CVD住院患者之间的关联以及归因于NO2的疾病负担分数。在我们学习期间，总CVD的平均每天住院人数（标准偏差）为488.2（117.1），179.8（45.6）用于缺血性心脏病，7.0（3.3）用于心律紊乱，13.2（7.2）用于心力衰竭，267.9（67.7）用于缺血性中风，和20.2（6.4）为出血性中风。NO2的10-μg/m3增加与在lag0-2天住院总CVD的1.9%的风险升高相关(RR:1.019,95%CI:1.005至1.032),2.1%（1.021，1.006至1.036）用于缺血性心脏病，缺血性中风为2.1%(1.021、1.006至1.035)，分别,虽然NO2与心律紊乱入院之间没有显著关联，心力衰竭,出血性中风.总CVD的可归属分数，缺血性心脏病,缺血性中风对NO2的影响为6.52％（1.87至10.94％），7.31%（2.19%至12.17%），和7.12%(2.14%至11.85%)，分别。我们的发现表明，农村人口的CVD负担也部分归因于短期暴露于NO2。需要在农村地区进行更多的研究来复制我们的发现。
