Abstract：
Survival outcomes for localized pancreatic adenocarcinoma remains poor. Multimodality therapeutic regimens are critical to maximizing survival outcomes for these patients, which includes the use of systemic therapy, surgery, and radiation. In this review, the evolution of radiation techniques are discussed with a focus on modern techniques such as intensity modulated radiation and stereotactic body radiation therapy. However, the current role of radiation within the most common clinical scenarios for pancreatic cancer in the neoadjuvant, definitive, and adjuvant settings continues to be highly debated. The role of radiation in these settings is reviewed in the context of historical and modern clinical studies. In addition, emerging concepts including dose-escalated radiation, magnetic resonance-guided radiation therapy, and particle therapy are discussed to promote an understanding of how such concepts may change the role of radiation in the future.
摘要：
局部胰腺腺癌的生存结果仍然很差。多模态治疗方案对于最大限度地提高这些患者的生存结果至关重要。包括全身治疗,手术,和辐射。在这次审查中,讨论了辐射技术的发展，重点是现代技术，如强度调制辐射和立体定向放射治疗。然而,目前放射在胰腺癌新辅助治疗中最常见的临床情景中的作用，最终，和佐剂设置仍然是高度争论。在历史和现代临床研究的背景下，对辐射在这些环境中的作用进行了回顾。此外,新兴的概念，包括剂量递增的辐射，磁共振引导放射治疗,和粒子疗法进行了讨论，以促进对这些概念如何改变未来辐射的作用的理解。
