Abstract：
Iatrogenic factors play an important role in H. pylori eradication failure, whereas it can be easily missed. Therefore, we aimed to investigate and analyze these related iatrogenic factors of H. pylori eradication failure.
A total of 508 patients who experienced H. pylori eradication failure were included in this study conducted from December 2019 to February 2022. All the patients filled out a questionnaire including demographic characteristics, duration of treatment, regimens, dosage, and time intervals in rescue treatment.
In the first-line treatment, 89 patients (17.5%, 89/508) used at least one antibiotic with high resistance rate in triple therapy and 57 patients (11.2%, 57/508) used two antibiotics with high resistance rates or other not recommended antibiotics in quadruple therapy. In the rescue therapy, 85 regimens were repeatedly used as salvage regimens in 58 patients (22.6%, 58/257) and 178 regimens containing antibiotics with high resistance rates were repeatedly used in 85 patients (33.1%, 85/257).
To decrease the risk of H. pylori eradication failure, iatrogenic factors need to gain more attention. Clinicians should enhance their education and training to standardize the treatment regimens, better manage the H. pylori infection, and improve the eradication rate eventually.
A total of 508 patients who experienced H. pylori eradication failure were included in this study conducted from December 2019 to February 2022. All the patients filled out a questionnaire including demographic characteristics, duration of treatment, regimens, dosage, and time intervals in rescue treatment.
In the first-line treatment, 89 patients (17.5%, 89/508) used at least one antibiotic with high resistance rate in triple therapy and 57 patients (11.2%, 57/508) used two antibiotics with high resistance rates or other not recommended antibiotics in quadruple therapy. In the rescue therapy, 85 regimens were repeatedly used as salvage regimens in 58 patients (22.6%, 58/257) and 178 regimens containing antibiotics with high resistance rates were repeatedly used in 85 patients (33.1%, 85/257).
To decrease the risk of H. pylori eradication failure, iatrogenic factors need to gain more attention. Clinicians should enhance their education and training to standardize the treatment regimens, better manage the H. pylori infection, and improve the eradication rate eventually.
摘要：
未经证实：医源性因素在幽门螺杆菌根除失败中起重要作用，而它很容易被错过。因此,我们旨在调查和分析幽门螺杆菌根除失败的相关医源性因素。
UNASSIGNED：在2019年12月至2022年2月进行的这项研究中，共纳入了508例幽门螺杆菌根除失败的患者。所有患者都填写了一份包括人口统计特征的问卷，治疗持续时间,方案，剂量,和抢救治疗的时间间隔。
UNASSIGNED：在一线治疗中，89名患者（17.5%，89/508）在三联疗法和57例患者中使用了至少一种高耐药率的抗生素（11.2％，57/508）在四联疗法中使用了两种耐药率高的抗生素或其他不推荐的抗生素。在抢救治疗中，58例患者反复使用85个方案作为抢救方案（22.6%，58/257）和178种耐药率高的抗生素方案在85例患者中重复使用（33.1％，85/257)。
未经批准：为了降低幽门螺杆菌根除失败的风险，医源性因素需要得到更多的关注。临床医生要加强教育培训,规范治疗方案,更好地管理幽门螺杆菌感染，最终提高根除率。
UNASSIGNED：在2019年12月至2022年2月进行的这项研究中，共纳入了508例幽门螺杆菌根除失败的患者。
UNASSIGNED：在一线治疗中，
未经批准：为了降低幽门螺杆菌根除失败的风险，
